Agents that stimulate phosphoinositide turnover also elevate cAMP in SK-N-SH human neuroblastoma cells.
Agents that stimulate phosphoinositide turnover also elevate cAMP in SK-N-SH human neuroblastoma cells.
复制标题
刺激磷酸肌醇更新的药物也会升高 SK-N-SH 人神经母细胞瘤细胞中的 cAMP。
DOI：
10.1016/0024-3205(92)90058-w
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发表时间：
1992
期刊：
影响因子：
6.1
通讯作者：
Yasumoto,T
中科院分区：
文献类型：
--
作者：
Baumgold,J;Paek,R;Yasumoto,T
Stimulation of m1 and of m3 muscarinic receptors has previously been shown to increase intracellular cAMP levels in a variety of cells. Although the mechanism underlying this response is not fully understood, it has been hypothesized to be secondary to the IP3-mediated rise in intracellular calcium. In order to determine whether other means of elevating intracellular calcium also raise cAMP levels, we stimulated SK-N-SH human neuroblastoma cells with bradykinin or with maitoxin. Both of these agents stimulated phospholipase C, stimulated inositol phosphate release and elevated cAMP levels, thus demonstrating that this cAMP response is not unique to muscarinic receptor stimulation.
