MORPHOLOGICAL OBSERVATIONS ON THE CEREBELLAR CORTEX
MORPHOLOGICAL OBSERVATIONS ON THE CEREBELLAR CORTEX
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DOI：
10.1002/cne.901090102
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发表时间：
1958-01-01
影响因子：
2.5
通讯作者：
ATWOOD, RP
中科院分区：
文献类型：
--
作者：
BRAITENBERG, V;ATWOOD, RP
两个垂直方向（晶格结构）的组织学分化是所有其他灰片中小脑皮层的特征。整个片材的一些几何不变量是：分子层的厚度恒定；浦肯野细胞数、分子层体积和颗粒层体积之间的恒定关系； “平行纤维”和浦肯野树突树的垂直方向；存在横跨叶的水平纤维系统（垂直于平行纤维）。由于叶状结构和平行纤维的方向实际上可以等同，因此平面投影上明显的叶状图案的扩张（蚓部前部，半球中心）和收缩（蚓部中部，片材边缘）以及叶状结构（后部蚓部）的不连续性表明组织学晶格的局部扭曲。哺乳动物小脑的简单区域细分可以基于整体晶格的这些局部扭曲。颗粒细胞和浦肯野细胞计数（分别为 1,000,000 和 300/mm,2）表明收敛性约为 3000/1。体积考虑表明平行纤维的长度不能超过 1-10 毫米。平行纤维的细度表明传导缓慢，浦肯野树的平行性和扁平化表明了时间-地点转换的机制，或叶方向的“定时拾取”。方法包括对福尔马林固定材料上的高尔基体反应进行新的修改。
Histological differentiation in two perpendicular directions (lattice structure) characterizes the cerebellar cortex among all other grey sheets. Some of the geometrical invariants throughout the whole sheet are: constant thickness of the molecular layer; constant relation between number of Purkinje cells, volume of molecular layer and volume of granular layer; perpendicular orientation of "parallel fibers" and Purkinje dendritic trees; existence of a horizontal fiber system oriented across the folium (perpendicular to parallel fibers). Since direction of foliation and of parallel fibers can practically be equated, expansion (anterior vermis, center of the hemisphere) and contraction (middle part of vermis, margin of the sheet) of the folial pattern evident on planar projections, as well as discontinuity of the folia (posterior vermis) indicate local distortions of the histological lattice. A simple regional subdivision of the mammalian cerebellum can be based on these local distortions of the overall lattice. Counts of granular and Purkinje cells (1,000,000 and 300/mm,2 respectively) suggest convergence of about 3000/1. Volumetric considerations suggest that parallel fibers cannot be longer than 1-10 mm. The thinness of parallel fibers, indicating slow conduction, the parallelity and flattening of Purkinje trees suggests a mechanism of time-place transformation, or "timed pick-up" in the folial direction. Methods include a new modification of the Golgi reaction on formalin fixed material.