Semantic processing in the left inferior prefrontal cortex: A combined functional magnetic resonance imaging and transcranial magnetic stimulation study
Semantic processing in the left inferior prefrontal cortex: A combined functional magnetic resonance imaging and transcranial magnetic stimulation study
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DOI：
10.1162/089892903321107837
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发表时间：
2003-01-01
影响因子：
3.2
通讯作者：
Rushworth, MFS
中科院分区：
文献类型：
--
作者：
Devlin, JT;Matthews, PM;Rushworth, MFS
左下前额叶皮层（LIPC）参与语音处理是建立在两个损伤缺陷的研究与神经系统患者和正常人的功能性神经影像学研究。另一方面，它在语义处理中的参与就不那么清楚了。虽然许多成像研究表明，LIPC激活在语义任务，这可能是由于内隐语音加工。本文提出了两个实验研究语义功能的LIPC。功能磁共振成像实验的结果表明，语义和语音处理激活了该区域内的一组共同的区域。此外，本发明还涉及一种用于该方法，在前LIPC中，语义决定相对于语音决定的激活有可靠的增加，而相反的比较（语音与语义的决定）揭示了一个区域的增强激活后LIPG第二个实验使用经颅磁刺激（TMS）暂时干扰LIPC前部的神经信息处理，以确定该区域是否是正常的语义性能重复和单脉冲TMS都显著减慢了被试对语义控制任务的反应，但对知觉控制任务的反应没有显著影响。我们的研究结果澄清了LIPC的功能解剖表明，前部和后部区域有助于语义和语音处理，虽然在不同程度上。此外，研究结果超越了简单地建立语义处理和激活之间的相关性，在LIPC和表明，短暂的中断处理选择性地干扰语义处理。
The involvement of the left inferior prefrontal cortex (LIPC) in phonological processing is well established from both lesion-deficit studies with neurological patients and functional neuroimaging studies of normals. Its involvement in semantic processing, on the other hand, is less clear. Although many imaging studies have demonstrated LIPC activation during semantic tasks, this may be due to implicit phonological processing. This article presents two experiments investigating semantic functions in the LIPC. Results from a functional magnetic resonance imaging experiment demonstrated that both semantic and phonological processing activated a common set of areas within this region. in addition, there was a reliable increase in activation for semantic relative to phonological decisions in the anterior LIPC while the opposite comparison (phonological vs. semantic decisions) revealed an area of enhanced activation within the posterior LIPG A second experiment used transcranial magnetic stimulation (TMS) to temporarily interfere with neural information processing in the anterior portion of the LIPC to determine whether this region was essential for normal semantic performance. Both repetitive and single pulse TMS significantly slowed subjects' reactions for the semantic but not for the perceptual control task. Our results clarify the functional anatomy of the LIPC by demonstrating that anterior and posterior regions contribute to both semantic and phonological processing, albeit to different extents. In addition, the findings go beyond simply establishing a correlation between semantic processing and activation in the LIPC and demonstrate that a transient disruption of processing selectively interfered with semantic processing.