BLOOD-FLOW CHANGES IN TRANSPLANTED MOUSE-TUMORS AND SKIN AFTER MILD HYPERTHERMIA
BLOOD-FLOW CHANGES IN TRANSPLANTED MOUSE-TUMORS AND SKIN AFTER MILD HYPERTHERMIA
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DOI：
10.1259/0007-1285-56-667-477
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发表时间：
1983-01-01
影响因子：
2.6
通讯作者：
BEGG, A
中科院分区：
文献类型：
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作者：
STEWART, F;BEGG, A
研究了中温对4种肿瘤类型和正常小鼠皮肤血管灌注量的影响。86Rb提取技术用于测量在42.5℃热处理1h期间和1h后，血流灌注量相对于总心输出量的变化。C.SA FA肿瘤的灌注量在加热的前30分钟内略有增加，但在1小时的加热期结束时已恢复到对照组的值。加热后2 4h，4种肿瘤的相对灌注量均显著低于对照组，并持续1~2d(SA FA肿瘤)，而后恢复至对照组。正常皮肤的相对灌注量在加热过程中逐渐增加，并在治疗结束后24小时内保持升高，然后恢复到对照水平。[使用热疗治疗癌症有很大的实验和临床兴趣。]。
The influence of moderate hyperthermia on the vascular perfusion of 4 tumor types and of normal mouse skin was investigated. The 86Rb extraction technique was used to measure changes in perfusion relative to total cardiac output, both during and after a 1 h heat treatment at 42.5.degree. C. Perfusion of the SA FA tumor increased slightly during the first 30 min of heating but had returned to control values by the end of a 1 h heating period. After heating, the relative perfusion of all 4 tumor types fell significantly below control values by 24 h and remained low for 1-2 days (SA FA tumor) before returning to control values. Relative perfusion of normal skin was progressively increased during heating and remained elevated for 24 h after the end of treatment before returning to control levels. [There is substantial experimental and clinical interest in the use of hyperthermia for the treatment of cancer.].