Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans
Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans
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DOI：
10.1182/blood-2009-03-211052
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发表时间：
2009-12-03
期刊：
影响因子：
20.3
通讯作者：
Pollard, Andrew J.
中科院分区：
文献类型：
--
作者：
Blanchard-Rohner, Geraldine;Pulickal, Anoop S.;Pollard, Andrew J.
在人类中，记忆B细胞和浆细胞在初次免疫期间出现的动力学还没有很好地定义。在这项研究中，我们评估了狂犬病抗原幼稚志愿者在接种3剂狂犬疫苗期间的初级b细胞反应，并与之前接种过狂犬疫苗的志愿者接种加强剂狂犬疫苗后的b细胞反应进行了比较。接种单剂疫苗后，未接种组血浆和记忆B细胞出现的时间（在第10天达到峰值）晚于接种组（在第7天达到峰值），出现频率也较低。在幼稚组中，在第三次免疫后检测到最快的反应（第4天）。这是第一个记录成人浆细胞和记忆b细胞对免疫反应的详细动力学的研究，并证明了与人先前存在的免疫状态相关的反应差异。（血液。2009;114:4998-5002）
In humans, the kinetics of the appearance of memory B cells and plasma cells during primary immunization are not well defined. In this study, we assessed the primary B-cell response of rabies-antigen naive volunteers during a 3-dose course of rabies vaccine compared with the B-cell response to a booster dose of rabies vaccine given to previously immunized volunteers. After a single dose of vaccine, in the naive group plasma and memory B cells appeared later (peak at day 10) than in the primed group (peak at day 7) and were at lower frequency. The most rapid responses (day 4) were detected after a third immunization in the naive group. This is the first study to document the detailed kinetics of the plasma cell and memory B-cell responses to immunization in adult humans and to demonstrate differences in the responses that relate to the preexisting immune status of the persons. (Blood. 2009; 114: 4998-5002)