Hemispheric asymmetry and homotopy of resting state functional connectivity correlate with visuospatial abilities in school-age children
Hemispheric asymmetry and homotopy of resting state functional connectivity correlate with visuospatial abilities in school-age children
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DOI：
10.1016/j.neuroimage.2018.03.051
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发表时间：
2018-07-01
期刊：
影响因子：
5.7
通讯作者：
Alcauter, Sarael
中科院分区：
文献类型：
--
作者：
Gracia-Tabuenca, Zeus;Moreno, Martha B.;Alcauter, Sarael
认知功能的半球特化是一个发育过程，它塑造了从妊娠期到成年期的大脑。静息态脑的功能连接性已被广泛用于推断自发脑活动的半球组织。特别是，两个主要的属性已在很大程度上探讨了整个发展：半球不对称的功能连接和同伦功能连接。然而，它们与特定的认知过程的关系通常与半球的专业化，如视觉空间能力，仍然在很大程度上未被探索。这种关系可能是特别相关的发展认知生物标志物在儿童时期，视觉空间能力的重要成熟期的追求。此外，大脑功能连接的不对称性和同伦之间的关系还没有得到很好的理解。我们已经检查了这两个属性的样本中的60个典型的发展中国家之间的6至10岁的儿童，并探讨了他们的关系与视觉空间能力。首先，我们确定了同伦和大脑不对称性之间的强烈负相关。此外，这些特性显示了大脑后部的区域，与视觉记忆和视觉注意力任务的表现有显着相关性。这些结果突出了大脑自发活动的半球组织的相关性发展认知，特别是视觉空间能力。
Hemispheric specialization of cognitive functions is a developmental process that shapes the brain from the gestational stage to adulthood. Functional connectivity of the resting brain has been largely used to infer the hemispheric organization of the spontaneous brain activity. In particular, two main properties have been largely explored throughout development: hemispheric asymmetry of functional connectivity and homotopic functional connectivity. However, their relation with specific cognitive processes typically associated with hemispheric specialization, such as visuospatial abilities, remains largely unexplored. Such relationships could be particularly relevant for the quest of developmental cognitive biomarkers in childhood, a significant maturation period of visuospatial abilities. Moreover, the relation between asymmetry and homotopy of brain functional connectivity is not well understood. We have examined these two properties in a sample of 60 typically developing children between 6 and 10 years of age, and explored their relation with visuospatial abilities. First, we identified a strong negative relation between homotopy and asymmetry across the brain. In addition, these properties showed areas in the posterior portion of the brain, with significant correlation with performance in visual memory and visual attention tasks. These results highlight the relevance of the hemispheric organization of spontaneous brain activity for developmental cognition, particularly for visuospatial abilities.