Longitudinal monitoring of motor neuron circuitry in FALS rats using in-vivo phMRI.
Longitudinal monitoring of motor neuron circuitry in FALS rats using in-vivo phMRI.
复制标题
使用体内 phMRI 纵向监测 FALS 大鼠的运动神经元回路。
DOI：
10.1097/wnr.0b013e328330eb9e
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发表时间：
2010
期刊：
影响因子：
1.7
通讯作者：
Jenkins,BruceG
中科院分区：
文献类型：
--
作者：
Choi,Ji-Kyung;Dedeoglu,Alpaslan;Jenkins,BruceG
肌萎缩侧索硬化症（ALS）的诊断和客观监测疾病进展提出了挑战。我们表明，使用药理学MRI，在运动电路的改变，其特点是使用被动刺激在大鼠模型的家族性ALS作为一个功能的症状进展。症状前家族性ALS大鼠对苯丙胺的激活模式与野生型对照组在统计学上无明显区别。相比之下，有症状的大鼠表现出显着降低的反应，在感觉运动皮层和M2运动皮层，尾状核/壳核，丘脑的反应增加。这些结果与人类ALS运动任务反应改变的结果相似。使用被动安非他明激发作为生物标志物来评估疾病进展和潜在治疗的有效性可能是合理的。
Amyotrophic lateral sclerosis (ALS) presents challenges for diagnosis and objective monitoring of disease progression. We show, using pharmacologic MRI, that alterations in motor circuitry can be characterized using a passive stimulus in a rat model of familial ALS as a function of symptom progression. Presymptomatic familial ALS rats had a pattern of activation to amphetamine that was statistically indistinguishable from the wild-type controls. In contrast, symptomatic rats showed significantly decreased response in sensorimotor cortex and increased response in M2 motor cortex, caudate/putamen, and thalamus. These results are similar to findings in humans of altered response to motor tasks in ALS. It may be plausible to use a passive amphetamine challenge as a biomarker to assess progression of the disease and efficacy of potential treatments.