Intracellular membrane fusion: SNAREs only?
Intracellular membrane fusion: SNAREs only?
复制标题
DOI：
10.1016/s0955-0674(99)80064-7
复制
发表时间：
1999-08-01
影响因子：
7.5
通讯作者：
Mayer, A
中科院分区：
文献类型：
--
作者：
Mayer, A
在过去的两年里，人们对细胞内膜融合的机制进行了大量的研究，其中SNARE复合物的作用受到了广泛的关注。它们的晶体结构被解决，融合使用蛋白脂质体与纯化的SNARE重建，表明它们是融合的最小机器。然而，对生理膜的研究指向了另一个方向，并引发了对SNARE功能的激烈争论。
The past two years have seen vigorous attempts to elucidate the mechanism driving intracellular membrane fusion, Much attention was focused on the role of SNARE complexes. Their crystal structure was solved and fusion was reconstituted using proteoliposomes with purified SNAREs suggesting them to be the minimal machinery for fusion. Work on physiological membranes, however, points in another direction and has spurred a hot debate on the function of SNAREs.