Brain connectome modularity in weight-restored anorexia nervosa and body dysmorphic disorder.
Brain connectome modularity in weight-restored anorexia nervosa and body dysmorphic disorder.
复制标题
体重恢复的神经性厌食症和身体变形障碍中的脑连接组模块化。
DOI：
10.1017/s0033291716001458
复制
发表时间：
2016
影响因子：
6.9
通讯作者：
Feusner,JD
中科院分区：
文献类型：
--
作者：
Zhang,A;Leow,A;Zhan,L;GadElkarim,J;Moody,T;Khalsa,S;Strober,M;Feusner,JD
BackgroundAnorexia nervosa (AN) and body dysmorphic disorder (BDD) frequently co-occur, and have several overlapping phenomenological features. Little is known about their shared neurobiology. The aim of the study was to compare modular organization of brain structural connectivity.MethodWe acquired diffusion-weighted magnetic resonance imaging data on unmedicated individuals with BDD (n = 29), weight-restored AN (n = 24) and healthy controls (HC) (n = 31). We constructed connectivity matrices using whole-brain white matter tractography, and compared modular structures across groups.ResultsAN showed abnormal modularity involving frontal, basal ganglia and posterior cingulate nodes. There was a trend in BDD for similar abnormalities, but no significant differences compared with AN. In AN, poor insight correlated with longer path length in right caudal anterior cingulate and right posterior cingulate.ConclusionsAbnormal network organization patterns in AN, partially shared with BDD, may have implications for understanding integration between reward and habit/ritual formation, as well as conflict monitoring/error detection.
