Development and Functions of Mitochondria in Early Life.
Development and Functions of Mitochondria in Early Life.
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DOI：
10.5005/jp-journals-11002-0013
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
He L
中科院分区：
文献类型：
--
作者：
Peng J;Ramatchandirin B;Pearah A;Maheshwari A;He L
线粒体是真核细胞中细菌起源的高度动态细胞器。它们在代谢和三磷酸腺苷（ATP）合成以及活性氧（ROS）的产生和调节中发挥核心作用。除了产生能量外，线粒体还执行许多其他功能，以支持关键的发育事件，如生殖过程中的受精、卵母细胞成熟和胚胎发育。在胚胎和新生儿发育过程中，线粒体可能在代谢、能量和表观遗传调控中发挥重要作用，这可能对胚胎和后代的健康产生显著的短期和长期影响。因此，环境、表观基因组和早期生命调节都与线粒体完整性、通讯和代谢有关。
Mitochondria are highly dynamic organelles of bacterial origin in eukaryotic cells. These play a central role in metabolism and adenosine triphosphate (ATP) synthesis and in the production and regulation of reactive oxygen species (ROS). In addition to the generation of energy, mitochondria perform numerous other functions to support key developmental events such as fertilization during reproduction, oocyte maturation, and the development of the embryo. During embryonic and neonatal development, mitochondria may have important effects on metabolic, energetic, and epigenetic regulation, which may have significant short- and long-term effects on embryonic and offspring health. Hence, the environment, epigenome, and early-life regulation are all linked by mitochondrial integrity, communication, and metabolism.