Maternal periconceptional alcohol consumption and risk for orofacial clefts
Maternal periconceptional alcohol consumption and risk for orofacial clefts
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DOI：
10.1016/s0022-3476(99)70453-1
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发表时间：
1999-03-01
影响因子：
5.1
通讯作者：
Lammer, EJ
中科院分区：
文献类型：
--
作者：
Shaw, GM;Lammer, EJ
Objective: To investigate whether periconceptional maternal alcohol consumption increased the risk of delivering infants with orofacial cleft phenotypes.Design: Data were derived from a large population-based case control study of fetuses and infants among a cohort of California births from 1987 to 1989 (n = 548,844). Information concerning alcohol consumption was obtained by telephone interviews with mothers of 731 infants (84.7% of eligible) with orofacial clefts and of 734 (78.2%) infants in a nonmalformed control group.Results: Thirty-nine percent of mothers in the case group and 42% of mothers in the control group reported that they consumed alcohol during the period 1 month before through 3 months after conception. Relative to nonconsumers, women who reported alcohol consumption (
