Uncertainty analysis of quantitative imaging features extracted from contrast-enhanced CT in lung tumors.
Uncertainty analysis of quantitative imaging features extracted from contrast-enhanced CT in lung tumors.
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DOI：
10.1016/j.compmedimag.2015.12.001
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发表时间：
2016-03
期刊：
影响因子：
--
通讯作者：
Court LE
中科院分区：
文献类型：
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作者：
Yang J;Zhang L;Fave XJ;Fried DV;Stingo FC;Ng CS;Court LE
评估从肺癌患者的对比增强计算机断层扫描（CT）扫描中提取的定量成像特征的不确定性，包括对对比剂注射后时间的依赖性和扫描之间的特征再现性。8例患者在间隔2-7天的两次会议上进行了肺部肿瘤的对比增强CT扫描。每个阶段包括每15秒对同一解剖结构进行6次CT扫描，从注射造影剂后50秒开始。基于灰度直方图、共生矩阵、邻域灰度差矩阵、游程矩阵和几何形状的图像特征从每次扫描的肿瘤中提取。斯皮尔曼相关性用于检查造影剂注射后特征对时间的依赖性，超过0.50的值被认为是时间依赖性的。计算一致性相关系数，以检查造影剂注射后扫描时间之间和扫描会话之间的每个特征的再现性，大于0.90的值被认为是可再现的。发现这些特征对造影剂注射和CT扫描之间的时间几乎没有依赖性。大多数特征在造影剂注射后的扫描时间之间和扫描会话之间是可再现的。当从造影剂注射后较长时间进行的CT扫描中提取某些特征时，其重现性更好。这里测试的定量成像特征大多是可再现的，并且对造影剂注射后的时间几乎没有依赖性。
To assess the uncertainty of quantitative imaging features extracted from contrast-enhanced computed tomography (CT) scans of lung cancer patients in terms of the dependency on the time after contrast injection and the feature reproducibility between scans. Eight patients underwent contrast-enhanced CT scans of lung tumors on two sessions 2–7 days apart. Each session included 6 CT scans of the same anatomy taken every 15 seconds, starting 50 seconds after contrast injection. Image features based on intensity histogram, co-occurrence matrix, neighborhood gray-tone difference matrix, run-length matrix, and geometric shape were extracted from the tumor for each scan. Spearman’s correlation was used to examine the dependency of features on the time after contrast injection, with values over 0.50 considered time-dependent. Concordance correlation coefficients were calculated to examine the reproducibility of each feature between times of scans after contrast injection and between scanning sessions, with values greater than 0.90 considered reproducible. The features were found to have little dependency on the time between the contrast injection and the CT scan. Most features were reproducible between times of scans after contrast injection and between scanning sessions. Some features were more reproducible when they were extracted from a CT scan performed at a longer time after contrast injection. The quantitative imaging features tested here are mostly reproducible and show little dependency on the time after contrast injection.