Dopamine D2 receptor availability and amphetamine-induced dopamine release in unipolar depression
Dopamine D2 receptor availability and amphetamine-induced dopamine release in unipolar depression
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DOI：
10.1016/s0006-3223(01)01089-7
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发表时间：
2001-09-01
影响因子：
10.6
通讯作者：
Laruelle, M
中科院分区：
文献类型：
--
作者：
Parsey, RV;Oquendo, MA;Laruelle, M
背景：多巴胺能传递减少与抑郁症的病理生理学有关。本研究的目的是测量非精神病性、未用药的单相抑郁症患者的纹状体D-2受体可用性和苯丙胺诱导的多巴胺释放。方法：D-2受体拮抗剂[I-123]的纹状体平衡特异性与非特异性分配系数（V-3”）采用单光子发射计算机断层扫描技术对9名抑郁症患者和10名健康对照者服用苯丙胺前后的IBZM进行检测。抑郁症患者（0.73 ± 0.08）和对照组（0.78 ± 0.10，p = 0.23）之间的前苯丙胺D-2受体可用性无显著差异。在抑郁症患者（-9.8 +/- 5.5%）和对照受试者（-7.8 +/-2.5%，p = 0.32）中，安非他明诱导的[I-123]IBZM V-3”（DeltaV（3）”）减少相似。安非他明可诱导抑郁症患者的脑功能短暂改善，但这种改善与[I-123]IBZM DeltaV无关（3）“结论：本研究未重复先前报道的抑郁症患者纹状体D-2受体密度的改变，并表明在重度抑郁症中，兴奋剂诱导的多巴胺释放未发生改变。生物精神病学2001;50：313-322（C）2001生物精神病学学会。
Background: Reduced dopaminergic transmission has been implicated in the pathophysiology of major depression. The aim of the present study was to measure striatal D-2 receptor availability and amphetamine-induced dopamine release in nonpsychotic, unmedicated, unipolar patients during an episode of major depression.Methods: The striatal equilibrium specific to nonspecific partition coefficient (V-3") of the D-2 receptor antagonist [I-123]IBZM was measured with single photon emission computerized tomography before and after amphetamine administration in 9 depressed subjects and 10 matched healthy control subjects.Results: No significant differences were observed in preamphetamine D-2 receptor availability between depressed patients (0.73 +/- 0.08) and control subjects (0.78 +/- 0.10, p =.23). Amphetamine-induced reduction in [I-123]IBZM V-3" (DeltaV(3)") was similar in depressed patients (-9.8 +/- 5.5%) and control subjects (-7.8 +/- 2.5%, p =.32). Amphetamine induced a transient improvement in symptomatology in depressed patients, but this improvement did not correlate with [I-123]IBZM DeltaV(3)"Conclusions: This study did not replicate previously reported alterations in striatal D-2 receptor density in depressed patients and suggests that stimulant-induced dopamine release is not altered in major depression. Biol Psychiatry 2001;50:313-322 (C) 2001 Society of Biological Psychiatry.