The neural response properties and cortical organization of a rapidly adapting muscle sensory group response that overlaps with the frequencies that elicit the kinesthetic illusion
The neural response properties and cortical organization of a rapidly adapting muscle sensory group response that overlaps with the frequencies that elicit the kinesthetic illusion
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DOI：
10.1371/journal.pone.0188559
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发表时间：
2017-11-28
期刊：
影响因子：
3.7
通讯作者：
Ina, Jason G.
中科院分区：
文献类型：
--
作者：
Marasco, Paul D.;Bourbeau, Dennis J.;Ina, Jason G.
动觉是肢体运动的感觉。它是有效运动控制的基础，但其神经生理成分仍然知之甚少。初级肌纺锤波和皮肤传入神经对动觉感觉的作用已经得到了很好的研究；然而，与肌肉纺锤波不同的肌肉感觉群反应的潜在贡献并没有被排除。在雄性斯普莱格·道利大鼠去手套前肢准备的周围神经和大脑的电生理记录提供了快速适应肌肉感觉群反应的证据，该反应与振动输入重叠，已知振动输入会产生人类肢体运动的错觉知觉（动觉错觉）。这组与Ia型肌纺锤体纤维的特征不同，Ia型肌纺锤体纤维历来被认为是肢体运动感觉的受体，这表明Ia型肌纺锤体纤维可能不是运动感觉信息的唯一载体。肌肉的感觉神经结构是复杂的，有许多可能的来源的反应组；高尔基肌腱器官是最有可能的人选。快速适应的肌肉感觉组反应投射到本体感觉区，即皮层3a区和第二体感区（S2）的啮齿动物同源区，大脑和周围神经之间具有相似的适应和频率响应谱。它们的代表性组织是肌肉特异性的（心肌），并在近端和多关节肢体关节中放大。投射到本体感觉脑区，容易出现运动错误的肌肉的心肌代表性放大，与虚幻的振动输入重叠，以及意志运动单元收缩的共振频率表明，这种群体反应可能与肢体运动加工有关。
Kinesthesia is the sense of limb movement. It is fundamental to efficient motor control, yet its neurophysiological components remain poorly understood. The contributions of primary muscle spindles and cutaneous afferents to the kinesthetic sense have been well studied; however, potential contributions from muscle sensory group responses that are different than the muscle spindles have not been ruled out. Electrophysiological recordings in peripheral nerves and brains of male Sprague Dawley rats with a degloved forelimb preparation provide evidence of a rapidly adapting muscle sensory group response that overlaps with vibratory inputs known to generate illusionary perceptions of limb movement in humans (kinesthetic illusion). This group was characteristically distinct from type Ia muscle spindle fibers, the receptor historically attributed to limb movement sensation, suggesting that type Ia muscle spindle fibers may not be the sole carrier of kinesthetic information. The sensoryneural structure of muscles is complex and there are a number of possible sources for this response group; with Golgi tendon organs being the most likely candidate. The rapidly adapting muscle sensory group response projected to proprioceptive brain regions, the rodent homolog of cortical area 3a and the second somatosensory area (S2), with similar adaption and frequency response profiles between the brain and peripheral nerves. Their representational organization was muscle-specific (myocentric) and magnified for proximal and multi-articulate limb joints. Projection to proprioceptive brain areas, myocentric representational magnification of muscles prone to movement error, overlap with illusionary vibrational input, and resonant frequencies of volitional motor unit contraction suggest that this group response may be involved with limb movement processing.