Mitochondrial transplantation for organ rescue
Mitochondrial transplantation for organ rescue
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DOI：
10.1016/j.mito.2022.02.007
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发表时间：
2022-02-25
期刊：
影响因子：
4.4
通讯作者：
Emani, Sitaram M.
中科院分区：
文献类型：
--
作者：
McCully, James D.;del Nido, Pedro J.;Emani, Sitaram M.
线粒体移植涉及用从患者自身获取的非缺血组织中分离出的具有呼吸能力的活性线粒体来替换或增强因缺血而受损的天然线粒体。移植的线粒体的摄取和细胞功能整合似乎发生在所有类型的细胞中。有效性和安全性已经在细胞培养、隔离灌流器官、体内大型动物研究和第一次人类临床研究中得到证实。在此，我们回顾了我们的发现，并为器官缺血-再灌注损伤的治疗提供了见解。
Mitochondrial transplantation involves the replacement or augmentation of native mitochondria damaged, by ischemia, with viable, respiration-competent mitochondria isolated from non-ischemic tissue obtained from the patient's own body. The uptake and cellular functional integration of the transplanted mitochondria appears to occur in all cell types. Efficacy and safety have been demonstrated in cell culture, isolated perfused organ, in vivo large animal studies and in a first-human clinical study. Herein, we review our findings and provide insight for use in the treatment of organ ischemia-reperfusion injury.