Performance on the Cogstate Brief Battery Is Related to Amyloid Levels and Hippocampal Volume in Very Mild Dementia
Performance on the Cogstate Brief Battery Is Related to Amyloid Levels and Hippocampal Volume in Very Mild Dementia
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DOI：
10.1007/s12031-016-0822-8
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发表时间：
2016-11-01
影响因子：
3.1
通讯作者：
Maruff, Paul
中科院分区：
文献类型：
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作者：
Lim, Yen Ying;Villemagne, Victor L.;Maruff, Paul
在一组患有非常轻度痴呆的老年人中，我们的目的是描述认知能力下降的性质和程度，如通过Cogstate Brief Battery测量的，与A β水平和海马体积有关。参与者根据他们在临床痴呆评定（CDR）量表上的状态进行表征。本研究共纳入308名CDR为0且大脑A β水平较低（A β-）的个体，32名A β-且CDR 0.5的个体，以及43名A β +且CDR 0.5的个体。参与者在基线以及18个月，36个月，54个月和72个月的随访时完成了CogState简短电池。线性混合模型分析表明，相对于A β- CDR 0组，A β + CDR 0.5组显示记忆力下降和海马体积损失的速率增加。然而，与A β- CDR 0组相比，A β- CDR 0. 5组在72个月内未显示认知功能或海马体积的变化。本研究的结果证实，在患有非常轻度痴呆症且也有A β +生物标志物确认的个体中，认知功能的变化主要表现为记忆处理的恶化，这与海马体积损失有关。相反，在患有非常轻度痴呆但为A β的个体中，没有任何认知下降或海马体积损失，这表明其他一些非AD疾病过程可能是认知功能中任何静态损伤的基础。
In a group of older adults with very mild dementia, we aimed to characterize the nature and magnitude of cognitive decline as measured by the Cogstate Brief Battery, in relation to A beta levels and hippocampal volume. Participants were characterized according to their status on the Clinical Dementia Rating (CDR) scale. A total of 308 individuals who were CDR 0 and had low cerebral A beta levels (A beta-), 32 individuals who were A beta- and CDR 0.5, and 43 individuals who were A beta+ and CDR 0.5 were included in this study. Participants completed the CogState brief battery at baseline, and at 18-, 36-, 54- and 72-month follow-up. Linear mixed model analyses indicated that relative to the A beta- CDR 0 group, the A beta+ CDR 0.5 group showed increased rates of memory decline and hippocampal volume loss. However, compared to the A beta- CDR 0 group, the A beta- CDR 0.5 group showed no changes in cognitive function or hippocampal volume over 72 months. The results of this study confirm that in individuals with very mild dementia, who also have biomarker confirmation of A beta+, changes in cognitive function manifest primarily as deterioration in memory processing, and this is associated with hippocampal volume loss. Conversely, the absence of any cognitive decline or loss in hippocampal volume in individuals with very mild dementia but who are A beta- suggests that some other non-AD disease process may underlie any static impairment in cognitive function.