Black and green tea consumption and the risk of coronary artery disease: a meta-analysis.
Black and green tea consumption and the risk of coronary artery disease: a meta-analysis.
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DOI：
10.3945/ajcn.110.005363
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发表时间：
2011-03
期刊：
影响因子：
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通讯作者：
Ze-Mu Wang;Bo Zhou;Yong-Sheng Wang;Qing-yue Gong;Qiming Wang;Jianjun Yan;Wei Gao;Lian-Sheng Wang
中科院分区：
文献类型：
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作者：
Ze-Mu Wang;Bo Zhou;Yong-Sheng Wang;Qing-yue Gong;Qiming Wang;Jianjun Yan;Wei Gao;Lian-Sheng Wang
背景：关于饮茶与冠心病（CAD）风险之间的关系，流行病学研究并不一致。目的：目的是进行荟萃分析，以确定观察性研究中茶摄入量与CAD总终点之间是否存在关联。我们检索PUBMED和EMBASE数据库中1966年至2009年11月进行的研究。使用随机效应模型将特定研究的风险估计结合起来。结果荟萃分析共纳入18项研究：13项关于红茶的研究，5项关于绿茶的研究。对于红茶，通过荟萃分析没有发现显著关联[最高与最低相比，总相对风险（RR）： 0.92；95% ci: 0.82, 1.04；增加1杯/d，总体RR: 0.98；95% ci: 0.94, 1.02]。对于绿茶，总风险比表明，最高的绿茶摄入量与CAD风险降低之间存在显著关联（总风险比：0.72；95%可信区间：0.58,0.89）。此外，每天多喝一杯绿茶，患冠心病的风险就会降低10%（总RR: 0.90; 95% CI: 0.82, 0.99）。结论：我们的数据不支持红茶对CAD的保护作用。关于绿茶的有限数据支持绿茶消费与降低冠心病风险的初步联系。然而，需要更多的研究来证明这种关联。
BACKGROUND Epidemiologic studies are inconsistent regarding the association between tea consumption and the risk of coronary artery disease (CAD). OBJECTIVE The objective was to perform a meta-analysis to determine whether an association exists between tea consumption and total CAD endpoints in observational studies. DESIGN We searched PUBMED and EMBASE databases for studies conducted from 1966 through November 2009. Study-specific risk estimates were combined by using a random-effects model. RESULTS A total of 18 studies were included in the meta-analysis: 13 studies on black tea and 5 studies on green tea. For black tea, no significant association was found through the meta-analysis [highest compared with lowest, summary relative risk (RR): 0.92; 95% CI: 0.82, 1.04; an increment of 1 cup/d, summary RR: 0.98; 95% CI: 0.94, 1.02]. For green tea, the summary RR indicated a significant association between the highest green tea consumption and reduced risk of CAD (summary RR: 0.72; 95% CI: 0.58, 0.89). Furthermore, an increase in green tea consumption of 1 cup/d was associated with a 10% decrease in the risk of developing CAD (summary RR: 0.90; 95% CI: 0.82, 0.99). CONCLUSIONS Our data do not support a protective role of black tea against CAD. The limited data available on green tea support a tentative association of green tea consumption with a reduced risk of CAD. However, additional studies are needed to make a convincing case for this association.