A more powerful robust sib-pair test of linkage for quantitative traits.
A more powerful robust sib-pair test of linkage for quantitative traits.
复制标题
数量性状连锁的更强大的稳健同胞对测试。
DOI：
10.1002/gepi.1370060306
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发表时间：
1989
影响因子：
2.1
通讯作者：
Bailey-Wilson,JE
中科院分区：
文献类型：
--
作者：
Amos,CI;Elston,RC;Wilson,AF;Bailey-Wilson,JE
Haseman 和 Elston 的方法 [Behav Genet 2(1):3–19, 1972] 开发了一种更强大的稳健连锁测试。这种新的稳健测试使用加权最小二乘（WLS）方法来检测数量性状和多态性标记之间的联系。为了进行比较，还研究了使用已知的父母性状基因型的连锁测试的特征。使用渐近结果计算的检测连锁所需的样本量与 1) 通常的 Haseman-Elston 方法、2) WLS 方法和 3) 使用亲本性状基因型数据的方法进行比较。 WLS 方法最多需要两倍于使用父母性状基因型信息的方法所需的同胞对数量。通过模拟研究了 Haseman-Elston (H-E) 和 WLS 检验的小样本特性。发现 H-E 方法的功效计算是准确的。当研究的同胞对少于 300 时，WLS 方法的功效被高估，但 WLS 方法仍然比通常的 H-E 方法更强大。在少于 300 个同胞对的样本中，WLS 检验往往是反保守的。将大小为 3 或 5 的同胞的所有同胞对视为独立不会增加检验的显着性。
A more powerful robust test for linkage is developed from the methodology of Haseman and Elston [Behav Genet 2(1):3–19, 1972]. This new robust test uses weighted least‐squares (WLS) methods to detect linkage between a quantitative trait and a polymorphic marker. For comparison, the characteristics of a test for linkage that uses known trait genotypes for the parents are also studied. Sample sizes needed to detect linkage, calculated using asymptotic results, are compared for 1) the usual Haseman‐Elston method, 2) the WLS method, and 3) the method that uses parental trait genotype data. The WLS method needs at most twice the number of sib pairs as does the method that used information on the trait genotypes of the parents. The small sample properties of the Haseman‐Elston (H‐E) and WLS tests are investigated by simulation. The power calculations for the H‐E method are found to be accurate. The power of the WLS method is overestimated when fewer than 300 sib pairs are studied, but the WLS method is nonetheless more powerful than the usual H‐E method. In samples of fewer than 300 sib pairs, the WLS test tends to be anticonservative. Treating all sib pairs from sibships of size 3 or 5 as independent does not increase the significance of the tests.