Curcumin inhibits the side population (SP) phenotype of the rat C6 glioma cell line: towards targeting of cancer stem cells with phytochemicals.
Curcumin inhibits the side population (SP) phenotype of the rat C6 glioma cell line: towards targeting of cancer stem cells with phytochemicals.
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DOI：
10.1016/j.canlet.2009.12.018
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发表时间：
2010-07-01
期刊：
影响因子：
9.7
通讯作者：
Chan, Marion M.
中科院分区：
文献类型：
--
作者：
Fong, Dunne;Yeh, Arthur;Naftalovich, Rotem;Choi, Theresa Hyejeong;Chan, Marion M.
植物化学物质姜黄素来自印度香料姜黄，具有许多生物学特性，包括抗炎和抗癌活性。我们研究了姜黄素对大鼠C6胶质瘤细胞系的影响。通过Hoechst 33342染料和流式细胞术分析处理的细胞和对照细胞。我们观察到C6细胞的侧群（SP）在每日姜黄素处理C6细胞后减少。在Hoechst试验期间，姜黄素与C6细胞直接孵育也降低了SP。由于SP与干细胞群体相关，姜黄素可能是一种具有靶向癌症干细胞潜力的膳食植物化学物质。
The phytochemical curcumin, from the Indian spice turmeric, has many biological properties, including anti-inflammatory and anti-carcinogenic activities. We have examined the effects of curcumin on the rat C6 glioma cell line. Treated and control cells were analyzed by Hoechst 33342 dye and flow cytometry. We observed a decrease in the side population (SP) of C6 cells after daily curcumin treatment of the C6 cells. Direct incubation of curcumin to C6 cells during the Hoechst assay also decreased SP. Since SP has been associated with stem cell populations, curcumin may be a dietary phytochemical with potential to target cancer stem cells.
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影响因子：
11.2
作者：
Folkins C;Shaked Y;Man S;Tang T;Lee CR;Zhu Z;Hoffman RM;Kerbel RS
通讯作者：
Kerbel RS
影响因子：
5.2
作者：
Bar, Eli E.;Chaudhry, Aneeka;Eberharta, Charles G.
通讯作者：
Eberharta, Charles G.
影响因子：
5.6
作者：
Chan, MM;Soprano, KJ;Fong, D
通讯作者：
Fong, D
影响因子：
20.3
作者：
Guzman, ML;Rossi, RM;Jordan, CT
通讯作者：
Jordan, CT
影响因子：
20.3
作者：
Hassane, Duane C.;Guzman, Monica L.;Jordan, Craig T.
通讯作者：
Jordan, Craig T.