Diterpenoid alkaloids.
Diterpenoid alkaloids.
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DOI：
10.1039/9781847555618-00256
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发表时间：
1986
影响因子：
11.9
通讯作者：
S. Pelletier;S. Page
中科院分区：
文献类型：
--
作者：
S. Pelletier;S. Page
在本报告所涉及的这一年里，二萜生物碱的化学，而不是通过物理方法来阐明它们的结构，引起了更多的兴趣。虽然已经报道了几种新的生物碱，但对这些多环、多官能团碱的研究大多涉及化学转化和合成方法。最值得注意的是，威斯纳在加拿大新不伦瑞克的团队报告了Delphinine类型生物碱的第四代合成。这一“合成工程”奇迹实现了这些复杂天然产物的高效、全区域和立体定向合成的目标，这一点非常清楚。已有报道称，从瑞香中提取出两种新的生物碱。*相关物种瑞香的植物与日本北海道的牛中毒事件有关。3综述了龙须草生物碱C2()二萜生物碱的化学和热分解合成二萜生物碱的最新进展。结构A、B、C和D中分别给出了乌头碱、柳珊瑚碱、乌头碱和维他命骨架的编号系统。这份报告调查了截至1980年7月在我们图书馆可获得的文献中报告的工作。
The chemistry of the diterpenoid alkaloids, rather than their structure elucidation by physical methods, has attracted more interest during the year covered by this Report. While several new alkaloids have been reported, most of the research on these polycyclic, polyfunctional bases has involved chemical conversions and synthetic methods. Most notably, Wiesner's group at New Brunswick, Canada, has reported a fourth-generation synthesis of the delphinine-type alkaloids. That this marvel of'synthetic engineering'accomplishes the stated goals' of a highly efficient, fully regio-and stereo-specific synthesis of these complex natural products is abundantly clear.Two new alkaloids from Daphniphyllum gracile Gage have been reported.* Plants of the related species Daphniphyllum humile Maxim have been implicated in cattle poisonings in Hokkaido, Japan. 3 Surveys of recent developments in the chemistry of C2 () diterpenoid alkaloid^,^ of the alkaloids of Consolida~ mbigua,~ and of the synthesis of diterpenoid alkaloids by thermolysis6 have appeared. The numbering systems for the aconitine, lycoctonine, atisine, and veatchine skeletons are presented in structures A, B, C, and D, respectively. This Report surveys the work reported in the literature that was available in our libraries up to July 1980.