Local heat application to the leg reduces muscle sympathetic nerve activity in human
Local heat application to the leg reduces muscle sympathetic nerve activity in human
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DOI：
10.1007/s00421-011-1852-0
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发表时间：
2011-09-01
影响因子：
3
通讯作者：
Tajima, Fumihiro
中科院分区：
文献类型：
--
作者：
Takahashi, Noriyo;Nakamura, Takeshi;Tajima, Fumihiro
该研究旨在评估局部加热 (LH) 对健康男性通过显微神经造影测量的节后肌肉交感神经活动 (MSNA) 的影响。在第一个方案中，记录了 9 名男性的左腓神经 MSNA、血压 (BP)、心率 (HR) 和胫骨皮肤温度 (TSK)。在第二个方案中，通过应变计体积描记法测量同一受试者的腿部血流量（LBF）。在这两种方案中，仰卧位休息 10 分钟后，将加热的水整理器包应用于胫骨和前足 15 分钟，并在 20 分钟内监测恢复情况。 LH 期间 TSK 从 31.7 +/- 0.1 逐渐升高至 41.9 +/- 0.5 摄氏度（平均值 +/- SEM）。没有受试者抱怨疼痛，血压和心率保持恒定。对照期间的 MSNA 突发率（16.1 +/- 2.1 次/分钟）在 LH 期间显着下降（P < 0.05）至 72.0 +/- 2.3%。 LH 期间总 MSNA 也下降至 59.2 +/- 2.6% (P < 0.05)，但在恢复时均立即恢复至基线。相比之下，应用 LH 后，左腿的 LBF 立即显着升高（P < 0.05），并保持显着升高直至恢复期结束。这些结果表明：(1) LH 应用显着减弱 MSNA，而 HR 和 BP 没有任何变化。 (2) 除了 MSNA 之外，其他因素似乎也控制 LH 期间下肢的局部血流。
The study was designed to assess the effects of local heat (LH) application on postganglionic muscle sympathetic nerve activity (MSNA) measured by microneurography in healthy men. In the first protocol, MSNA of the left peroneal nerve, blood pressure (BP), heart rate (HR), and skin temperature of the shin (TSK) were recorded in nine men. In the second protocol, leg blood flow (LBF) was measured in the same subjects by strain-gauge plethysmography. In both protocols, after 10 min of rest in the supine position, a heated hydrocollator pack was applied to the shin and anterior foot for 15 min and recovery was monitored over a period of 20 min. TSK gradually increased from 31.7 +/- 0.1 to 41.9 +/- 0.5 degrees C (mean +/- SEM) during LH. No subject complained of pain, and BP and HR remained constant. The MSNA burst rate (16.1 +/- 2.1 beats/min) during the control period decreased significantly (P < 0.05) to 72.0 +/- 2.3% during LH. Total MSNA also decreased to 59.2 +/- 2.6% (P < 0.05) during LH, but both immediately returned to baseline at recovery. In contrast, LBF in the left leg significantly and immediately increased (P < 0.05) after LH application and remained significantly elevated until the end of the recovery period. These results suggest that: (1) LH application significantly attenuates MSNA without any changes in HR and BP. (2) Other factors in addition to MSNA seem to control regional blood flow in the lower extremity during LH.