STUDIES ON MECHANISM OF INHIBITION OF GLUTAMINE SYNTHETASE BY METHIONINE SULFOXIMINE
STUDIES ON MECHANISM OF INHIBITION OF GLUTAMINE SYNTHETASE BY METHIONINE SULFOXIMINE
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DOI：
10.1021/bi00831a038
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发表时间：
1969-01-01
期刊：
影响因子：
2.9
通讯作者：
MEISTER, A
中科院分区：
文献类型：
--
作者：
RONZIO, RA;ROWE, WB;MEISTER, A
Robert A. Ronzio，t W.布鲁斯罗和奥尔顿迈斯特摘要：谷氨酰胺合成酶（来自羊脑）被甲硫氨酸砜和甲硫氨酸亚砜亚胺显著抑制。与甲硫氨酸砜相反，甲硫氨酸亚砜亚胺不可逆地抑制酶。谷氨酸盐降低了不可逆抑制的速率，而氨（或羟胺）不影响不可逆抑制的速率，但谷氨酸盐和氨的混合物可以有效地防止抑制。
Robert A. Ronzio, t W. Bruce Rowe, and Alton Meister abstract: Glutamine synthetase (from sheep brain) is markedly inhibited by methionine sulfone and by methionine sulfoximine. In contrast to methionine sulfone, methionine sulfoximineinhibits the enzyme ir-reversibly. The rate at which irreversible inhibition is established is decreased by glutamate and unaffected by ammonia (or hydroxylamine), but a mixture of both glutamate and ammonia can effectively prevent inhibition.