Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics.
Targeting IRES-Mediated p53 Synthesis for Cancer Diagnosis and Therapeutics.
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DOI：
10.3390/ijms18010093
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发表时间：
2017-01-04
影响因子：
5.6
通讯作者：
Yang DQ
中科院分区：
文献类型：
--
作者：
Ji B;Harris BR;Liu Y;Deng Y;Gradilone SA;Cleary MP;Liu J;Yang DQ
虽然 DNA 损伤后 p53 5′非翻译区的内部核糖体进入位点 (IRES) 对 p53 的翻译调节已被广泛接受，但其 IRES 序列对 p53 翻译控制的详细机制仍知之甚少。在这篇综述中，我们将重点关注鉴定 p53 IRES 的新型调节蛋白以及揭示缺陷 IRES 介导的 p53 翻译与肿瘤发生之间的功能联系的最新进展。我们还将讨论这些发现如何有助于更好地理解肿瘤发生过程，并为癌症诊断和治疗开辟新途径。
While translational regulation of p53 by the internal ribosome entry site (IRES) at its 5′-untranslated region following DNA damage has been widely accepted, the detailed mechanism underlying the translational control of p53 by its IRES sequence is still poorly understood. In this review, we will focus on the latest progress in identifying novel regulatory proteins of the p53 IRES and in uncovering the functional connection between defective IRES-mediated p53 translation and tumorigenesis. We will also discuss how these findings may lead to a better understanding of the process of oncogenesis and open up new avenues for cancer diagnosis and therapeutics.