Metabolomic and secretomic approach to the resistance features of the fungus Aspergillus niger IOC 4687 to copper stress
Metabolomic and secretomic approach to the resistance features of the fungus Aspergillus niger IOC 4687 to copper stress
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DOI：
10.1093/mtomcs/mfaa010
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发表时间：
2021-01-01
期刊：
影响因子：
3.4
通讯作者：
Mendes, Maria Anita
中科院分区：
文献类型：
--
作者：
Cota de Almeida, Silas Perdigao;Rozas, Enrique Eduardo;Mendes, Maria Anita
对尼日尔IOC 4687进行了代谢组学和分泌组学分析，结果表明该菌株具有抗铜胁迫的特性。为了研究氧化应激条件下产生的代谢物，进行了气相色谱-质谱分析。分泌组主成分分析结果表明，甘露醇可能是赋予该菌抗性的主要代谢产物，而葡萄糖酸可能是铜解吸的原因，因为其具有螯合能力。对A.尼日尔IOC 4687指出，生长过程中低浓度的山梨糖醇和核糖内酯可能是氧化应激的指标。
Metabolomic and secretomic analyses of Aspergillus niger IOC 4687 indicated the features of resistance of this strain to copper stress. To investigate the metabolites produced under oxidative stress conditions, gas chromatography-mass spectrometry analysis was performed. The secretome principal component analysis results showed that mannitol could be the main metabolite responsible for conferring resistance to the fungus, and gluconic acid is the possible cause of copper desorption because of its chelating ability. The meta-analysis of the metabolome of A. niger IOC 4687 indicated that a low concentration of sorbitol and ribonolactone during growth may be an indicator of oxidative stress.