Gene-environment interaction between APOA5 c.553G>T and pregnancy in hypertriglyceridemia-induced acute pancreatitis
Gene-environment interaction between APOA5 c.553G>T and pregnancy in hypertriglyceridemia-induced acute pancreatitis
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APOA5c.553G>T 与妊娠在高甘油三酯血症诱发的急性胰腺炎中基因与环境的相互作用
DOI：
10.1016/j.jacl.2020.05.003
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发表时间：
2020-07-01
影响因子：
4.4
通讯作者：
Li, Jie-Shou
中科院分区：
文献类型：
--
作者：
Pu, Na;Yang, Qi;Li, Jie-Shou
背景：高甘油三酯血症（HTG）及其诱发的急性胰腺炎（HTG- ap）的病因是复杂的。目的：探讨APOA5 c.553G基因与环境之间可能存在的相互作用。T (p.185Gly。Cys, rs2075291)是HTG-AP中甘油三酯水平改变与妊娠相关的常见变异。方法：我们纳入318例中国HTG-AP患者，将其分为3个不同的组：第一组，男性患者（n=183）；第二组为与妊娠无关的女性患者（n=105）；第三组为与妊娠相关的女性患者（n=30）。通过Sanger测序确定APOA5 rs2075291基因型状态。以362名健康汉族为对照。收集每位患者的体重指数、峰值甘油三酯水平、发病年龄、发作次数和HTG-AP的临床严重程度等数据。在患者组之间、患者组与对照组之间或每个患者组内进行多次比较。结果：APOA5 rs2075291与妊娠期的HTG-AP，尤其是HTG-AP有很强的相关性。较小的Tallele与第3组患者的相关性强于第1组和第2组患者。这种较强的相关性主要是由于第3组患者TT基因型的频率（20%）比第2组患者高得多。
BACKGROUND: The etiology of hypertriglyceridemia (HTG) and, consequently, HTG-induced acute pancreatitis (HTG-AP), is complex.OBJECTIVE: Herein, we explore a possible gene-environment interaction between APOA5 c.553G.T (p.185Gly.Cys, rs2075291), a common variant associated with altered triglyceride levels, and pregnancy in HTG-AP.METHODS: We enrolled 318 Chinese HTG-AP patients and divided them into 3 distinct groups: Group 1, male patients (n=183); Group 2, female patients whose disease was unrelated to pregnancy (n=105); and Group 3, female patients whose disease was related to pregnancy (n=30). APOA5 rs2075291 genotype status was determined by Sanger sequencing. A total of 362 healthy Han Chinese subjects were used as controls. Data on body mass index, peak triglyceride level, age of disease onset, episode number, and clinical severity of HTG-AP were collected from each patient. Multiple comparisons, between patient groups, between patient groups and controls, or within each patient group, were performed.RESULTS: A robust association of APOA5 rs2075291 with HTG-AP in general, and HTG-AP during pregnancy in particular, was demonstrated. The minor Tallele showed a stronger association with Group 3 patients than with either Group 1 or Group 2 patients. This stronger association was due mainly to the much higher frequency of TT genotype in Group 3 patients (20%) than that (