Infrared Plasmonic Biosensor for Real-Time and Label-Free Monitoring of Lipid Membranes
Infrared Plasmonic Biosensor for Real-Time and Label-Free Monitoring of Lipid Membranes
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DOI：
10.1021/acs.nanolett.5b05316
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发表时间：
2016-02-01
期刊：
影响因子：
10.8
通讯作者：
Altug, Hatice
中科院分区：
文献类型：
--
作者：
Limaj, Odeta;Etezadi, Dordaneh;Altug, Hatice
在这项工作中，我们提出了一种红外等离子体生物传感器，用于对仿生类脂膜的化学特异性检测和实时监测。脂膜是介导细胞信号传递以及与药物和病原体相互作用的主要生物界面。通过利用工程和表面修饰纳米天线附近的等离子体增强效应，所提出的生物传感器能够捕捉到脂质分子的振动指纹，并实时监测水环境中平面仿生膜的形成动力学。此外，我们还展示了这种等离子体生物传感器的高场增强特性，其距离表面超过几十纳米，在保持高灵敏度的同时与典型生物检测的大小相匹配。
In this work, we present an infrared plasmonic biosensor for chemical-specific detection and monitoring of biomimetic lipid membranes in a label-free and real-time fashion. Lipid membranes constitute the primary biological interface mediating cell signaling and interaction with drugs and pathogens. By exploiting the plasmonic field enhancement in the vicinity of engineered and surface-modified nanoantennas, the proposed biosensor is able to capture the vibrational fingerprints of lipid molecules and monitor in real time the formation kinetics of planar biomimetic membranes in aqueous environments. Furthermore, we show that this plasmonic biosensor features high-field enhancement extending over tens of nano meters away from the surface, matching the size of typical bioassays while preserving high sensitivity.