Autoradiography imaging in targeted alpha therapy with Timepix detector.
Autoradiography imaging in targeted alpha therapy with Timepix detector.
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DOI：
10.1155/2015/612580
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发表时间：
2015
影响因子：
--
通讯作者：
Brown MP
中科院分区：
文献类型：
--
作者：
A L Darwish R;Staudacher AH;Bezak E;Brown MP
缺乏与靶向α治疗中的活性摄取和粒子径迹分布相关的数据。需要这些数据来估计细胞水平上的吸收剂量，因为α粒子具有有限的范围并且仅穿过少数细胞。使用Timepix半导体辐射探测器可以跟踪单个α粒子。我们研究了用钍-227（使用APOMAB）治疗的小鼠肿瘤切片中α粒子发射成像的可行性，有和没有先前的化疗和Timepix检测器。此外，还研究了Timepix检测器基于坏死组织体积监测肿瘤摄取变化的灵敏度。基于获得的成像数据，使用房室分析模型来评估Th-227摄取。结果表明，α粒子，光子，电子和μ子的轨道检测和解决的Timepix探测器。目前的研究表明，由靶向α治疗产生的单个α粒子发射可以使用Timepix检测器进行可视化和定量。此外，已观察到基于肿瘤坏死体积的摄取变化，其中用化疗预处理的肿瘤的摄取比未化疗的肿瘤高四倍。
There is a lack of data related to activity uptake and particle track distribution in targeted alpha therapy. These data are required to estimate the absorbed dose on a cellular level as alpha particles have a limited range and traverse only a few cells. Tracking of individual alpha particles is possible using the Timepix semiconductor radiation detector. We investigated the feasibility of imaging alpha particle emissions in tumour sections from mice treated with Thorium-227 (using APOMAB), with and without prior chemotherapy and Timepix detector. Additionally, the sensitivity of the Timepix detector to monitor variations in tumour uptake based on the necrotic tissue volume was also studied. Compartmental analysis model was used, based on the obtained imaging data, to assess the Th-227 uptake. Results show that alpha particle, photon, electron, and muon tracks were detected and resolved by Timepix detector. The current study demonstrated that individual alpha particle emissions, resulting from targeted alpha therapy, can be visualised and quantified using Timepix detector. Furthermore, the variations in the uptake based on the tumour necrotic volume have been observed with four times higher uptake for tumours pretreated with chemotherapy than for those without chemotherapy.
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影响因子：
3.5
作者：
Esposito, M.;Mettivier, G.;Russo, P.
通讯作者：
Russo, P.
DOI：
10.1016/j.nima.2008.07.079
发表时间：
2008-10-01
影响因子：
1.4
作者：
Ruegheimer, Tilman K.;Gebert, Ulrike;Joram, Christian
通讯作者：
Joram, Christian
影响因子：
3.7
作者：
Al-Ejeh F;Darby JM;Tsopelas C;Smyth D;Manavis J;Brown MP
通讯作者：
Brown MP
影响因子：
3.2
作者：
Staudacher AH;Al-Ejeh F;Fraser CK;Darby JM;Roder DM;Ruszkiewicz A;Manavis J;Brown MP
通讯作者：
Brown MP
DOI：
10.1016/j.nima.2007.08.079
发表时间：
2007-10-21
影响因子：
1.4
作者：
Llopart, X.;Ballabriga, R.;Wong, W.
通讯作者：
Wong, W.