Soy protein isolate and protection against cancer
Soy protein isolate and protection against cancer
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DOI：
10.1080/07315724.2005.10719456
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发表时间：
2005-04-01
影响因子：
3.5
通讯作者：
Simmen, FA
中科院分区：
文献类型：
--
作者：
Badger, TM;Ronis, MJJ;Simmen, FA
目的：流行病学和动物研究的结果表明，食用含大豆的饮食可以降低某些癌症的发病率。这次演讲的目的是评估大豆蛋白预防前列腺癌，乳腺癌和结肠癌发生的潜力。方法：对已发表的将癌症风险与大豆摄入量联系起来的流行病学研究进行荟萃分析。用酪蛋白或大豆分离蛋白（SPI）制成的AIN-93G饲料喂养大鼠，测定化学诱导的乳腺或结肠肿瘤的发生率。对大鼠乳腺和结肠组织进行了Western和Northern blot和微阵列分析，以研究大豆作用的机制。结果：荟萃分析显示，食用大豆的人患乳腺癌（0.78,p < 0.001）、结肠癌（0.70,p < 0.001）和前列腺癌（0.66,p < 0.001）的平均总风险估计降低。添加spi的大鼠aom诱导的结肠肿瘤和dmba诱导的乳腺肿瘤发生率降低（p < 0.05）。spi喂养大鼠乳腺肿瘤发生率降低与：1)终末芽数减少（p < 0.05）， 2) I期酶CYPIB1表达降低（p < 0.05）， 3) Ah受体和ARNT表达降低（p < 0.05）有关。结论：SPI可能通过多种机制发挥抗癌作用，包括：1)促进乳腺分化；2)降低致癌物对致癌物的激活；3)调节肿瘤发生信号转导通路中的基因。升职和/或晋升。
Objective: Results from epidemiological and animal studies suggest that consuming soy-containing diets reduces the incidence of certain cancers. The purpose of this presentation was to evaluate the potential of soy protein to prevent occurrence of prostate, breast and colon cancer.Methods: Meta-analyses of published epidemologic studies associating cancer risk with soy intake were per-formed. The incidence of chemically-induced mammary or colon tumors was determined for rats fed AIN-93G diets made with either casein or soy protein isolate (SPI). Western and Northern blot and microarray analyses were performed on rat mammary and colon tissues to study mechanisms underlying the effects of soy.Results: Meta-analyses revealed reductions in the mean overall risk estimate for mammary (0.78, p < 0.001), colon (0.70, p < 0.001) and prostate (0.66, p < 0.001) cancer for soy consumers. The incidence of AOM-induced colon tumors and DMBA-induced mammary tumors was reduced (p < 0.05) in rats fed SPI-containing diets. Lower incidence of mammary tumors in SPI-fed rats was associated with: 1) reduced terminal end bud numbers (p < 0.05), 2) lower expression of the phase I enzyme CYPIB1 (p < 0.05) and 3) reduced expression of the Ah Receptor and ARNT (p < 0.05).Conclusions: SPI may protect against cancer via multiple mechanisms, including: 1) increased mammary gland differentiation, 2) decreased activation of procarcinogens to carcinogens and 3) regulation of genes in signal transduction pathways underlying tumor initiation. promotion and/or progression.