Effects of Increasing Exercise Intensity and Dose on Multiple Measures of HDL (High-Density Lipoprotein) Function
Effects of Increasing Exercise Intensity and Dose on Multiple Measures of HDL (High-Density Lipoprotein) Function
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DOI：
10.1161/atvbaha.117.310307
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发表时间：
2018-04-01
影响因子：
8.7
通讯作者：
Rohatgi, Anand
中科院分区：
文献类型：
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作者：
Sarzynski, Mark A.;Ruiz-Ramie, Jonathan J.;Rohatgi, Anand
目的 HDL（高密度脂蛋白）功能的测量与心血管疾病相关。然而，经常锻炼对这些措施的影响在很大程度上尚不清楚。因此，我们在 2 项随机临床运动试验中检查了不同剂量的运动对 HDL 功能 3 项指标的影响。 方法和结果 在 2 个队列的 6 个月运动训练之前和之后评估了放射性标记和二氟化硼标记的胆固醇流出能力和 HDL-apoA-I（载脂蛋白 A-I）交换：STRRIDE-PD（通过限定运动进行有针对性的风险降低干预措施的研究，针对患有以下疾病的个体）糖尿病前期；n=106）和 E-MECHANIC（运动引起的体重补偿机制检查；n=90）。 STRRIDE-PD 参与者完成了 4 项数量和强度不同的运动干预中的 1 项。 E-MECHANIC 参与者被随机分为 2 个运动组中的 1 个（每周 8 或 20 kcal/kg）或对照组。 STRRIDE-PD 的高剂量/剧烈强度组 (35 mg/dL；P=0.02) 中 HDL-C 显着升高，而 E-MECHANIC 中未观察到 HDL-C 变化。在 STRRIDE-PD 中，与所有其他 STRRIDE-PD 组（范围，-2.4 至 -8.4%；SEM，0.06）相比，高剂量/高强度组的总体放射性标记流出能力显着增加 6.2%（SEM，0.06）。在 E-MECHANIC 中，与对照组相比，每周 20 kcal/kg 组中非 ABCA1（ATP 结合盒转运蛋白 A1）放射性标记的流出量显着增加 5.7%（95% CI，1.2-10.2%），而每周 8 kcal/kg 组没有变化（2.6%；95% CI，-1.4 至 6.7%）。当调整 HDL-C 的变化时，这种关联性被减弱。在这两项研究中，运动训练均不影响 BODIPY 标记的胆固醇流出能力或 HDL-apoA-I 交换。 结论 定期进行长时间剧烈运动可改善 HDL 功能的部分指标，但并非全部指标。未来的研究有必要调查运动对心血管疾病的影响是否部分是通过改善高密度脂蛋白功能来介导的。
Objective Measures of HDL (high-density lipoprotein) function are associated with cardiovascular disease. However, the effects of regular exercise on these measures is largely unknown. Thus, we examined the effects of different doses of exercise on 3 measures of HDL function in 2 randomized clinical exercise trials.Approach and Results Radiolabeled and boron dipyrromethene difluoride-labeled cholesterol efflux capacity and HDL-apoA-I (apolipoprotein A-I) exchange were assessed before and after 6 months of exercise training in 2 cohorts: STRRIDE-PD (Studies of Targeted Risk Reduction Interventions through Defined Exercise, in individuals with Pre-Diabetes; n=106) and E-MECHANIC (Examination of Mechanisms of exercise-induced weight compensation; n=90). STRRIDE-PD participants completed 1 of 4 exercise interventions differing in amount and intensity. E-MECHANIC participants were randomized into 1 of 2 exercise groups (8 or 20 kcal/kg per week) or a control group. HDL-C significantly increased in the high-amount/vigorous-intensity group (35 mg/dL; P=0.02) of STRRIDE-PD, whereas no changes in HDL-C were observed in E-MECHANIC. In STRRIDE-PD, global radiolabeled efflux capacity significantly increased 6.2% (SEM, 0.06) in the high-amount/vigorous-intensity group compared with all other STRRIDE-PD groups (range, -2.4 to -8.4%; SEM, 0.06). In E-MECHANIC, non-ABCA1 (ATP-binding cassette transporter A1) radiolabeled efflux significantly increased 5.7% (95% CI, 1.2-10.2%) in the 20 kcal/kg per week group compared with the control group, with no change in the 8 kcal/kg per week group (2.6%; 95% CI, -1.4 to 6.7%). This association was attenuated when adjusting for change in HDL-C. Exercise training did not affect BODIPY-labeled cholesterol efflux capacity or HDL-apoA-I exchange in either study.Conclusions Regular prolonged vigorous exercise improves some but not all measures of HDL function. Future studies are warranted to investigate whether the effects of exercise on cardiovascular disease are mediated in part by improving HDL function.