CONTROL OF CARDIAC-MUSCLE CELL-DIVISION
CONTROL OF CARDIAC-MUSCLE CELL-DIVISION
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DOI：
10.1016/1050-1738(92)90030-v
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发表时间：
1992-11-01
影响因子：
9.3
通讯作者：
CLAYCOMB, WC
中科院分区：
文献类型：
--
作者：
CLAYCOMB, WC
成年哺乳动物中终末分化的心室心肌细胞的分裂和增殖在损伤（例如由心肌梗塞引起的损伤）后不被激活。我们不知道在早期发育过程中，这些肌细胞的有丝分裂是如何被不可逆地阻断的。与骨骼肌不同，哺乳动物的心肌不能再生。了解控制心肌细胞周期的机制将使我们能够设计试剂或程序来启动损伤后成人心肌的修复或再生。理想情况下，我们希望能够将完整心肌中的心肌细胞恢复到它们在早期胎儿生长期间活跃分裂和增殖的生化状态。本文简要回顾了目前已知的机制，如此紧密地抑制这些高度分化的细胞的有丝分裂活动。
Division and proliferation of the terminally differentiated ventricular heart muscle cell in the adult mammal is not activated after injury such as that caused by a myocardial infarction. We do not understand how mitosis is irreversibly blocked in these myocytes during early development. Mammalian cardiac muscle, unlike skeletal muscle, cannot regenerate. Knowledge of the mechanisms that control the cardiac myocyte cell cycle would allow us to design reagents or procedures to initiate repair or regeneration of the adult myocardium following injury. Ideally, we would like to be able to revert cardiac muscle cells in intact heart muscle to the biochemical state they were in during early fetal growth when they were actively dividing and proliferating. This article briefly reviews what is currently known about the mechanism which so tightly suppresses the mitotic activity of these highly differentiated cells.