Neurobehavioral manifestations of developmental impairment of the brain.
Neurobehavioral manifestations of developmental impairment of the brain.
复制标题
DOI：
10.2478/v10102-010-0012-4
复制
发表时间：
2010-06
影响因子：
--
通讯作者：
Dubovický M
中科院分区：
文献类型：
--
作者：
Dubovický M
人性的个体特征（例如内向、外向、情绪、活动能力、适应性、攻击性、社交能力、焦虑）不一定主要是先天的。它们可由多种影响及其相互作用对大脑功能发育的作用所决定。有大量的流行病学和实验证据表明，在大脑发育的敏感时间段起作用的化学和/或物理因素可导致精神、行为、情绪和/或认知障碍。据报道，环境污染物、成瘾物质、药物、营养不良、过度应激和/或缺氧缺血会诱发大脑功能发育不良，进而导致神经行为障碍。本文综述了胎儿期、围产期和出生后早期大脑发育受损的最重要的神经行为表现。讨论了在人类以及实验动物中导致发育性神经行为功能障碍的最常见的不利因素。
Individual characteristics of human nature (e.g. introversion, extroversion, mood, activity, adaptability, aggressiveness, social ability, anxiety) do not need to be primarily innate. They can be determined by the action of various influences and their interactions on functional development of the brain. There is ample epidemiological and experimental evidence that chemical and/or physical factors acting during sensitive time windows of the brain development can cause mental, behavioral, emotional and/or cognitive disorders. Environmental pollutants, addictive substances, drugs, malnutrition, excessive stress and/or hypoxia-ischemia were reported to induce functional maldevelopment of the brain with consequent neurobehavioral disorders. The article provides review on most significant neurobehavioral manifestations of developmental impairment of the brain during prenatal, perinatal and early postnatal period. The most known adverse factors causing developmental neurobehavioral dysfunctions in humans as well as in experimental animals are discussed.