Repeatability and reproducibility of anterior chamber angle measurement with anterior segment optical coherence tomography
Repeatability and reproducibility of anterior chamber angle measurement with anterior segment optical coherence tomography
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DOI：
10.1136/bjo.2007.118901
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发表时间：
2007-11-01
影响因子：
4.1
通讯作者：
Lam, Dennis Shun Chiu
中科院分区：
文献类型：
--
作者：
Li, Haitao;Leung, Christopher Kai Shun;Lam, Dennis Shun Chiu
目的：评价前段光学相干层析成像测量前房角的重复性和再现性。方法：选取25名正常受试者，在一周内三次就诊，随机选取一只眼进行前房角OCT成像。在第一次访问时，每只眼睛在室内光（光强度= 368勒克斯）下成像三次，在黑暗中成像三次。在随后的访问中，每只眼睛在光照下和黑暗中分别成像一次。单观察者测量角度开启距离（AOD 500）和小梁-虹膜角（TIA 500）。仅分析鼻角。计算组内和组间标准偏差（Sw）、精密度（1.96xSw）、变异系数（CVw） （1006Sw/总平均值）和组内相关系数（ICC），以评价重复性和再现性。结果：光下AOD/TIA的Sw、精密度、CVw和ICC分别为45 μ m/2.4度、88 μ m/4.7度、5.8%/4.8%和0.97/0.95；45亩/2.1度、88亩/4.2度、7.0%/5.0%、0.98/0.97。间歇重现性方面，光下AOD/TIA的Sw、精密度、CVw和ICC分别为79 μ m/3.5°、155 μ m/6.8°、10.0%/7.0%、0.91/0.89；64亩/3.4度、124亩/6.6度、9.9%/7.8%、0.95/0.92。结论：前段OCT在不同光照条件下测量前房角可靠，重复性和再现性好。
Aim: To evaluate the repeatability and reproducibility of anterior chamber angle measurement obtained by anterior segment optical coherence tomography.Methods: Twenty-five normal subjects were invited for anterior chamber angle imaging with an anterior segment optical coherence tomography (OCT) on one randomly selected eye in three separate visits within a week. Each eye was imaged three times under room light ( light intensity = 368 lux) and three times in the dark during the first visit. In the subsequent visits, each eye was imaged once in the light and once in the dark. The angle opening distance (AOD 500) and the trabecular-iris angle (TIA 500) were measured by a single observer. Only the nasal angle was analysed. Intrasession and intersession within-subject standard deviation (Sw), precision (1.96xSw), coefficient of variation (CVw) (1006Sw/overall mean), and intraclass correlation coefficient (ICC) were calculated to evaluate repeatability and reproducibility.Results: For intrasession repeatability, the Sw, precision, CVw and ICC of AOD/TIA were 45 mu m/2.4 degrees, 88 mu m/4.7 degrees, 5.8%/4.8% and 0.97/0.95 in the light; and 45 mu m/2.1 degrees, 88 mu m/4.2 degrees, 7.0%/5.0% and 0.98/0.97 in the dark. For intersession reproducibility, the Sw, precision, CVw and ICC of AOD/TIA were 79 mu m/3.5 degrees, 155 mu m/6.8 degrees, 10.0%/7.0%, 0.91/0.89 in the light; and 64 mu m/3.4 degrees, 124 mu m/6.6 degrees, 9.9%/7.8% and 0.95/0.92 in the dark.Conclusions: The anterior segment OCT demonstrated reliable anterior chamber angle measurement in different lighting conditions with good repeatability and reproducibility.