FISH-OIL DIETARY SUPPLEMENTATION IN PATIENTS WITH RAYNAUD PHENOMENON - A DOUBLE-BLIND, CONTROLLED, PROSPECTIVE-STUDY
FISH-OIL DIETARY SUPPLEMENTATION IN PATIENTS WITH RAYNAUD PHENOMENON - A DOUBLE-BLIND, CONTROLLED, PROSPECTIVE-STUDY
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DOI：
10.1016/0002-9343(89)90261-1
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发表时间：
1989-02-01
影响因子：
5.9
通讯作者：
SHAH, DM
中科院分区：
文献类型：
--
作者：
DIGIACOMO, RA;KREMER, JM;SHAH, DM
摄入 omega-3 脂肪酸可以使患有雷诺现象的患者受益，因为除了其他作用外，这些脂肪酸还可以诱导对缺血的有利血管反应。我们研究的目的是以双盲、安慰剂对照的方式研究鱼油脂肪酸饮食疗法对风湿病患者的效果。 32 名患有原发性或继发性雷诺现象的患者被随机分配到橄榄油安慰剂组或鱼油组。患者每天摄入 12 粒鱼油胶囊，共含有 3.96 克二十碳五烯酸和 2.64 克二十二碳六烯酸或 12 粒橄榄油胶囊，并在基线以及 6、12 和 17 周后进行评估。所有患者在第12周至第17周之间摄入橄榄油。使用应变计体积描记法在40°C、25°C、15°C和10°C的室内空气和水浴中测量数字收缩压和血流量。雷诺现象的发生用秒表计时，并定义为研究手指中血流和血压停止的体积描记证据。在鱼油组中，雷诺现象出现之前的中位时间间隔从 31.3 .+- 增加。 1.3 分钟基线至 46.5 .+-。六周时为 2.1 分钟 (p = 0.04)。原发性雷诺现象患者摄入鱼油后，发病前的时间间隔增加最多。 11 名患有原发性雷诺现象的患者中，有 5 名 (45.5%) 在摄入鱼油后在基线时诱发了该现象，在 6 周或 12 周就诊时无法诱导出现雷诺现象，而 9 名患有原发性雷诺现象的患者 (11%) 摄入橄榄油时则有 1 名 (p = 0.05)。在10°C水浴中，摄入鱼油的原发性雷诺现象患者的平均指收缩压高于摄入橄榄油的原发性雷诺现象患者（+32毫米汞柱，p = 0.02）。我们得出的结论是，摄入鱼油可以提高原发性而非继发性雷诺现象患者对寒冷暴露的耐受性并延迟血管痉挛的发生。这些改善与寒冷温度下数字收缩压的显着升高有关。
The ingestion of omega-3 fatty acids could benefit patients with Raynaud''s phenomenon because, among other effects, these fatty acids induce a favorable vascular response to ischemia. The aim of our study was to investigate, in a double-blind, placebo-controlled manner, the effects of fish-oil fatty-acid dietary therapy in patients with rheumatic disease. Thirty-two patients with primary or secondary Raynaud''s phenomenon were randomly assigned to olive-oil placebo or fish-oil groups. Patients ingested 12 fish-oil capsules daily containing a tatal of 3.96 g eicosapentaenoic acid and 2.64 g docosahexaenoic acid or 12 olive-oil capsules and were evaluated at baseline and after six, 12, and 17 weeks. All patients ingested olive oil between Weeks 12 to 17. Digital systolic blood pressures and blood flow were measured at room air and water baths of 40.degree.C, 25.degree.C, 15.degree.C, and 10.degree.C using strain gauge plethysmography. Onset of Raynaud''s phenomenon was timed with a stop watch and defined as plethysmographic evidence of cessation of blood flow and blood pressure in the study finger. In the fish-oil group, the median time interval before the onset of Raynaud''s phenomenon increased from 31.3 .+-. 1.3 minutes baseline to 46.5 .+-. 2.1 minutes at six weeks (p = 0.04). Patients with primary Raynaud''s phenomenon ingesting fish oil had the greatest increase in the time interval before the onset of the conditions. Five of 11 patients (45.5 percent) with primary Raynaud''s phenomenon ingesting fish oil in whom the phenomenon was induced at baseline could not be induced to develop Raynaud''s at the six- or 12-week visit compared with one of nine patients (11 percent) with primary Raynaud''s ingesting olive oil (p = 0.05). The mean digital systolic pressures were higher in the patients with primary Raynaud''s phenomenon ingesting fish oil than in patients with primary Raynaud''s ingesting olive oil in the 10.degree.C water bath (+32 mm Hg, p = 0.02). We conclude that the ingestion fish oil improves tolerance to cold exposure and delays the onset of vasospasm in patients with primary, but not secondary, Raynaud''s phenomenon. These improvements are associated with significantly increased digital systolic blood pressure in cold temperatures.