Evaluation of thrombocytopenia in systemic lupus erythematosus and correlation with different organs damages.
Evaluation of thrombocytopenia in systemic lupus erythematosus and correlation with different organs damages.
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DOI：
10.5455/msm.2014.26.122-124
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发表时间：
2014-04
期刊：
影响因子：
--
通讯作者：
Roshi E
中科院分区：
文献类型：
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作者：
Ktona E;Barbullushi M;Backa T;Idrizi A;Shpata V;Roshi E
血小板减少症在系统性红斑狼疮（SLE）患者中非常普遍，同时有报道称血小板减少症与器官损伤之间存在相关性。本研究的目的是强调血小板减少症与 SLE 临床表现之间的相关性。目的是显示已发现患有血小板减少症的系统性红斑狼疮 (SLE) 患者的临床表现和器官损害。一项回顾性研究检查了特蕾莎修女医院中心风湿病科诊断和治疗的所有系统性红斑狼疮患者的病历。所有数据均来自出院患者图表。数据包括Anti DNA、AAN、C3、血小板减少、白细胞减少和器官损伤。数据取自2009年至2013年。所有患者的诊断均采用美国风湿病学会的分类标准。 330 名患者中，男性 12 名（3.64%），女性 318 名（96.3%）。其中73例患者有血小板减少症作为病例，257例SLE患者无血小板减少症作为对照组。与对照组相比，血小板减少症患者的 AAN 68（93.1%）、Anti DNA 50（64.3%）、C3 46 低值（63%）和白细胞减少症较高（p<0.05）。 血小板减少症患者中 48 例（65.7%）发生狼疮性肾炎，10 例（13.6%）伴有肺部受累，42 例（57.5%）有白细胞减少症。血小板减少症与任何疾病活动性、器官损伤和死亡率没有直接关系，但应将其视为一种预后因素，有助于识别病程可能加重的患者类别。
Thrombocytopenia is highly prevalent among patients with Systemic Lupus Erythematous(SLE) and at the same time it has been reported that a correlation exists between Thrombocytopenia and organ damage. The aim of this study is to highlight the correlation between Thrombocytopenia and the clinical manifestations of SLE. The objective is to show the clinical manifestations and organ damage of Systemic Lupus Erythematous (SLE) patients who have been found to have Thrombocytopenia. A retrospective study was conducted examining all patient charts diagnosed and treated for SLE at the Rheumatology Service of Mother Teresa Hospital Centre. All the data were collected from discharged patient charts. The data included were Anti DNA,AAN,C3 , thrombocytopenia, leucopenia, and organ damage. Data were taken from 2009 to 2013. The classification criteria of the American College of Rheumatology was used for all patients regarding the diagnosis. Out of 330 patients, 12 (3.64%) are men and 318 (96.3%) women. 73 of all patients have thrombocytopenia as cases and 257 patients had SLE without thrombocytopenia, which was considered as the control group. AAN 68(93.1%), Anti DNA 50 (64.3%) , low value of C3 46 (63%), and leucopenia were higher in thrombocytopenic patients compared with control group (p<0.05) 48 (65.7%) of thrombocytopenic patients develop lupus nephritis, 10 (13.6%) were with pulmonary involvement, and 42 (57.5%) had leukopenia. Thrombocytopenia is not directly associated with any disease activity, organ damage and mortality, but it should be considered as a prognostic factor which may help identifying a category of patients whose disease course can be aggravated.