Does the incidence of frailty differ between men and women over time?
Does the incidence of frailty differ between men and women over time?
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DOI：
10.1016/j.archger.2022.104880
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发表时间：
2022-12-06
影响因子：
4
通讯作者：
Alexandre, Tiago da Silva
中科院分区：
文献类型：
--
作者：
de Oliveira, Dayane Capra;Maximo, Roberta de Oliveira;Alexandre, Tiago da Silva
背景/目的：脆弱组分的发病机制、危险因素及性别对其的影响尚不完全清楚。本研究的目的是分析与脆性成分数量增加相关的因素的性别差异。方法：对ELSA研究中年龄60岁的1,747名参与者进行了12年的跟踪分析，在基线水平上没有脆弱。以社会经济、行为、临床和生化特征为暴露变量，用广义线性混合模型对脆弱成分按性别分层的增加进行分析。结果：男女脆弱成分数量的增加与年龄较高(70~79岁和80岁或以上)、低教育水平、久坐不动的生活方式、抑郁症状增加、关节疾病、高C反应蛋白水平、视力差和糖尿病失控有关(p<；0.05)。骨质疏松症、低体重、心脏病、与一个或多个人生活在一起以及感觉听力不佳与男性脆弱成分的数量增加有关。女性患者的预后与纤维蛋白原浓度高、糖尿病得到控制、中风和视力正常相关(p<；0.05)。与理想体重范围相比，肥胖男女和超重女性的脆弱成分数量增加较少。结论：社会经济因素、肌肉骨骼疾病、心脏病和低体重似乎支持男性的脆弱过程，而心血管和神经内分泌疾病似乎支持女性的脆弱过程。
Background/Objective: The mechanisms, risk factors and influence of sex on the incidence of frailty components are not fully understood. The aim of this study was to analyse sex differences in factors associated with the increase in the number of frailty components. Methods: A 12-year follow-up analysis was conducted with 1,747 participants aged >= 60 of the ELSA Study with no frailty at baseline. Generalised linear mixed models were used to analyse the increase in the number of frailty components stratified by sex, considering socioeconomic, behavioural, clinical and biochemical characteristics as exposure variables.Results: The increase in the number of frailty components in both sexes was associated with an advanced age (70 to 79 years and 80 years or older), low educational level, sedentary lifestyle, elevated depressive symptoms, joint disease, high C-reactive protein levels, perception of poor vision and uncontrolled diabetes (p < 0.05). Osteoporosis, low weight, heart disease, living with one or more people and perception of poor hearing were associated with an increase in the number of frailty components in men. High fibrinogen concentration, controlled diabetes, stroke and perception of fair vision were associated with the outcome in women (p < 0.05). Obese women and men and overweight women had a lower increase in the number of frailty components compared to those in the ideal weight range.Conclusions: Socioeconomic factors, musculoskeletal disorders, heart disease and low weight seem to sustain the frailty process in men, whereas cardiovascular and neuroendocrine disorders seem to sustain the frailty process in women.