Salp15, an Ixodes scapularis salivary protein, inhibits CD4+ T cell activation
Salp15, an Ixodes scapularis salivary protein, inhibits CD4+ T cell activation
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DOI：
10.1016/s1074-7613(02)00325-4
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发表时间：
2002-06-01
期刊：
影响因子：
32.4
通讯作者：
Fikrig, E
中科院分区：
文献类型：
--
作者：
Anguita, J;Ramamoorthi, N;Fikrig, E
蜱的唾液具有多效性，有利于节肢动物对宿主的持久性。我们现在描述一种肩胛硬蜱唾液中的摄食诱导蛋白Salp 15，其抑制CD 4（+）T细胞活化。该机制涉及抑制TCR连接引发的钙流，并导致白细胞介素-2的产生减少。Salp 15还抑制体内CD 4 + T细胞介导的免疫应答的发展，证明了这种蛋白质的功能重要性。Salp 15为了解肩突乳杆菌唾液的免疫抑制活性和载体-宿主相互作用提供了分子基础。
Tick saliva has pleiotropic properties that facilitate persistence of the arthropod upon the host. We now describe a feeding-inducible protein in Ixodes scapularis saliva, Salp15, that inhibits CD4(+) T cell activation. The mechanism involves the repression of calcium fluxes triggered by TCR ligation and results in lower production of interleukin-2. Salp15 also inhibits the development of CD4+ T cell-mediated immune responses in vivo, demonstrating the functional importance of this protein. Salp15 provides a molecular basis for understanding the immunosuppressive activity of L scapularis saliva and vector-host interactions.