Risk of asthma and allergic outcomes in the offspring in relation to maternal food consumption during pregnancy: A Finnish birth cohort study
Risk of asthma and allergic outcomes in the offspring in relation to maternal food consumption during pregnancy: A Finnish birth cohort study
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DOI：
10.1111/j.1399-3038.2012.01272.x
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发表时间：
2012-03-01
影响因子：
4.4
通讯作者：
Virtanen, Suvi M.
中科院分区：
文献类型：
--
作者：
Erkkola, Maijaliisa;Nwaru, Bright I.;Virtanen, Suvi M.
工作背景：流行病学和免疫学研究表明，母亲在怀孕期间的饮食可能会影响后代过敏性疾病的发展。作者着手研究母亲在怀孕期间的食物消费对儿童哮喘和过敏国际研究（ISAAC）的过敏结局的影响：5岁时的哮喘，过敏性鼻炎和喘息。研究方法：来自2441名5岁儿童的数据在芬兰1型糖尿病预测和预防（DIPP）营养研究中进行了分析，这是一项基于人群的出生队列研究。母亲的饮食进行了评估与验证的食物频率问卷。结果如下：在调整了已知混杂因素的多元回归模型中，（校正比值比[aOR]：1.55; 95% CI：1.21，1.98），苹果类水果（aOR：1.45; 95%CI：1.15，1.84）和巧克力（aOR：1.36; 95%CI：1.09，1.70）与儿童喘息风险呈正相关。母亲大量饮用果汁和浆果汁与儿童过敏性鼻炎的风险呈正相关（aOR：1.40; 95%CI：1.03，1.90）。没有观察到母亲的食物消耗和哮喘之间的关联。结论：学龄前儿童过敏性疾病的发生可能受到宫内暴露于母亲饮食的影响。
Background: Epidemiological and immunological studies suggest that maternal diet during pregnancy might affect the development of allergic diseases in the offspring. The authors set out to study the effect of maternal food consumption during pregnancy on the emergence of the International Study of Asthma and Allergies in Childhood (ISAAC)-based allergic outcomes: asthma, allergic rhinitis, and wheeze by the 5 yr of age. Methods: Data from 2441 children at 5 yr of age were analyzed within the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) Nutrition Study, a population-based birth cohort study. Maternal diet was assessed with a validated food frequency questionnaire. Results: In multiple regression models adjusted for known confounders, low maternal consumption of leafy vegetables (adjusted odds ratio [aOR]: 1.55; 95% CI: 1.21, 1.98), malaceous fruits (aOR: 1.45; 95% CI: 1.15, 1.84), and chocolate (aOR: 1.36; 95% CI: 1.09, 1.70) were positively associated with the risk of wheeze in children. High maternal consumption of fruit and berry juices was positively associated with the risk of allergic rhinitis (aOR: 1.40; 95% CI: 1.03, 1.90) in children. No associations were observed between maternal food consumption and asthma. Conclusions: Development of allergic diseases in preschool children may be influenced by intrauterine exposure to maternal diet.