AOPP and its relations with selected markers of oxidative/antioxidative system in type 2 diabetes mellitus
AOPP and its relations with selected markers of oxidative/antioxidative system in type 2 diabetes mellitus
复制标题
DOI：
10.1016/j.diabres.2006.12.007
复制
发表时间：
2007-08-01
影响因子：
5.1
通讯作者：
Warwas, Maria
中科院分区：
文献类型：
--
作者：
Piwowar, Agnieszka;Knapik-Kordecka, Maria;Warwas, Maria
背景：本研究的目的是评估 T2DM 氧化/抗氧化系统的选定成分；估计它们之间的关系；方法：在 94 名糖尿病患者和 36 名健康人中，测定了作为抗氧化防御标志物的 TRAP 血浆水平，以及作为氧化蛋白损伤 (OPD) 标志物的 CO、SH、NH2 组和 AOPP 的浓度。结果：与对照组相比，患者的 TRAP 和 SH 组水平显着较低，而 NH2、CO 和 AOPP 水平较高。在 TRAP 和 SH 组与 AOPP 之间以及 AOPP 与 SH 和 CO 组之间观察到显着相关性。 AOPP 浓度在大血管病和肥胖亚组中显着较高。结论：我们的结果支持糖尿病是一种具有氧化/抗氧化防御障碍的复杂代谢性疾病的观点。在研究的参数中，AOPP 显示糖尿病患者血浆中表现最明显的升高，并且在患有血管并发症和超重的亚组之间存在显着差异。我们可以得出结论，AOPP 似乎被认为是评估糖尿病患者 OPD 程度的有用标记。 (C) 2007 年，爱思唯尔爱尔兰有限公司出版。
Background: The aim of this study was to evaluate the selected components of the oxidative/antioxidative system in T2DM; estimation of relationships between them; search for the more expressive one and examine their alterations in angiopathy and obesity.Methods: In 94 diabetic patients and 36 healthy people, plasma levels of TRAP, as a marker of antioxidative defence, as well as concentrations of CO, SH, and NH2 groups and AOPP, as markers of oxidative protein damage (OPD) were determined.Results: Patients had significantly lower levels of TRAP and SH groups, as well as higher NH2, CO and AOPP in comparison to control. Significant correlation was observed between TRAP and SH groups and AOPP as well as between AOPP and SH and CO groups. Concentration of AOPP was significantly higher in the macroangiopathy and obese subgroups.Conclusions: Our results support the idea that diabetes mellitus is a complex metabolic disorder with oxidant/antioxidant defence disturbances. Among the studied parameters AOPP showed the most expressive raise in plasma of diabetic patients and significant differences between their subgroups with vascular complications and overweight. We can conclude that AOPP seems to be considered as a useful marker to estimate the degree of OPD in diabetic patients. (C) 2007 Published by Elsevier Ireland Ltd.