Narrowing in on compulsions: dopamine receptor functions.
Narrowing in on compulsions: dopamine receptor functions.
复制标题
缩小强迫范围：多巴胺受体功能。
DOI：
10.1037/a0014190
复制
发表时间：
2008
影响因子：
2.3
通讯作者：
Woods,JamesH
中科院分区：
文献类型：
--
作者：
Collins,GregoryT;Woods,JamesH
A series of experiments in rats explored the possibility that D3/D2 dopamine receptors are involved in behaviors that might be related to compulsion. A series of D3/D2 agonists and antagonists were shown to elicit yawning (D3-receptor mediated) and its inhibition (D2-receptor mediated). In rats with histories of cocaine exposure, D3-agonist-elicited yawning was enhanced, and quinpirole led to persistent operant responding only if conditioned stimuli associated with cocaine were presented for responding. Finally, a more selective D3 partial agonist was reported that had a novel profile of activity that could have relevance to the suppression of dopamine-related compulsions.(PsycINFO Database Record (c) 2016 APA, all rights reserved)
