Photothermal therapy by using titanium oxide nanoparticles
Photothermal therapy by using titanium oxide nanoparticles
复制标题
使用二氧化钛纳米颗粒进行光热疗法
DOI：
10.1007/s12274-016-1019-8
复制
发表时间：
2016-05-01
期刊：
影响因子：
9.9
通讯作者：
Wu, Hui
中科院分区：
文献类型：
--
作者：
Ou, Gang;Li, Zhiwei;Wu, Hui
光热疗法（photothermal therapy，PTT）被认为是一种很有前途的肿瘤治疗方法。然而，阻碍其临床应用的障碍之一是现有的重金属和碳基治疗剂的不可降解性和生物毒性。因此，迫切需要具有高光热效率、低毒性和良好生物相容性的PTT材料。在此，我们报道了一种用于PTT过程的具有高功效和低毒性的基于氧化钛的治疗剂。在小鼠体内实验中，我们证明了电弧熔炼法制备的Magnéli相Ti 8 O 15纳米粒子对近红外光的吸收率大于98%，并具有良好的上级光热治疗效果。Ti 8 O 15纳米颗粒PTT材料也表现出良好的生物相容性和生物安全性。我们的研究揭示了Magnéli相氧化钛作为PTT试剂的新家族，并介绍了氧化钛用于光热转化的新应用。
The photothermal therapy (PTT) technique is regarded as a promising method for cancer treatment. However, one of the obstacles preventing its clinical application is the non-degradability and biotoxicity of the existing heavy-metal and carbon-based therapeutic agents. Therefore, a PTT material with a high photothermal efficiency, low toxicity, and good biocompatibility is urgently wanted. Herein, we report a titanium oxide-based therapeutic agent with a high efficacy and low toxicity for the PTT process. We demonstrated that Magnéli-phase Ti8O15nanoparticles fabricated by the arc-melting method exhibit >98% absorption of near infrared light and a superior photothermal therapy effect in thein vivomouse model. The Ti8O15nanoparticle PTT material also shows a good biocompatibility and biosafety. Our study reveals Magnéli-phase titanium oxide as a new family of PTT agents and introduces new applications of titanium oxides for photothermal conversion.