Mouse somatosensory cortex: Development of the alterations in the barrel field which are caused by injury to the vibrissal follicles
Mouse somatosensory cortex: Development of the alterations in the barrel field which are caused by injury to the vibrissal follicles
复制标题
小鼠体感皮层：由触毛毛囊损伤引起的桶状区域变化的发展
DOI：
10.1016/0304-3940(77)90010-6
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发表时间：
1977
影响因子：
2.5
通讯作者：
H. Loos
中科院分区：
文献类型：
--
作者：
D. Jeanmonod;F. Rice;H. Loos
当新生小鼠的神秘触须的毛囊受到损伤时，成年和青少年的初级体感皮层（SI）发生了深刻的改变：通常由对应于受伤毛囊的桶所占据的区域是一个无桶区域。我们的问题是：这个区域从一开始就没有桶，还是桶开始发育，然后消失？在将损伤置于50只新生动物中并在整个出生后早期发育过程中分析它们的桶区域后，我们发现对应于受损毛囊的桶区域。受损的卵泡永远不会发育。取而代之的是，从一开始就形成了一个无桶域，以及与未病变毛囊相对应的相邻正常桶。
When the follicles of the mystacial vibrissae of newborn mice have been injured, the adult and adolescent primary somatosensory cortex (SI) is profoundly altered: the region normally occupied by the barrels that correspond to be injured follicles is a barrelless domain.Our question was: is this domain barrelless from the start, OR do barrels begin to develop, and then disappear?After placing lesions in 50 newborn animals and analyzing their barrel fields throughout early postnatal development, we found that barrels corresponding to the lesioned follicles never develop. In their stead a barrelless domain developsfrom the beggnning, along with the adjacent normal barrels that correspond to the unlesioned follicles.