SIGNIFICANCE OF ANTIBODIES TO CARDIOLIPIN IN UNSELECTED PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS - CLINICAL AND LABORATORY ASSOCIATIONS
SIGNIFICANCE OF ANTIBODIES TO CARDIOLIPIN IN UNSELECTED PATIENTS WITH SYSTEMIC LUPUS-ERYTHEMATOSUS - CLINICAL AND LABORATORY ASSOCIATIONS
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DOI：
10.1007/bf00286765
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发表时间：
1995-05-01
影响因子：
4
通讯作者：
STANNATKIESSLING, S
中科院分区：
文献类型：
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作者：
SACHSE, C;LUTHKE, K;STANNATKIESSLING, S
在一项多中心研究中，抗心磷脂抗体的IgG和IgM同种型的固相酶免疫法测定368例系统性红斑狼疮（SLE）谁没有选择的基础上的抗磷脂综合征的特点。抗心磷脂抗体水平升高的临床和实验室相关性进行了评价。分别在224例（60.9%）和128例（34.8%）患者中记录了心磷脂IgG和IgM抗体。抗心磷脂IgG水平升高与自然流产（P < 0.001）、血小板减少（P <0.01）、网状青斑（P <0.01）和直接Coombs试验阳性（P < 0.05）显著相关，但与血栓形成或癫痫、精神病等中枢神经系统疾病无关。抗心磷脂IgM抗体阳性与直接Coombs试验阳性相关（P < 0.01），但与抗磷脂综合征的其他症状无关。抗心磷脂抗体测定对SLE患者抗磷脂综合征的所有特征的预测价值都很差，因为假阳性和假阴性结果的比例很高。至于SLE的其他表现，双链DNA抗体和IgG同种型抗心磷脂抗体的发生呈正相关，抗心磷脂IgM与肾炎呈负相关。
In a multicentre study anticardiolipin antibodies of the IgG and IgM isotypes were measured by a solid phase enzyme immunoassay in 368 patients with systemic lupus erythematosus (SLE) who were not selected on the basis of features of antiphospholipid syndrome. Clinical and laboratory associations of increased levels of anticardiolipin antibodies were evaluated. IgG and IgM antibodies to cardiolipin were documented in 224 (60.9%) and 128 (34.8%) patients, respectively. Regarding the symptoms of antiphospholipid syndrome, elevated amounts of anticardiolipin IgG were significantly associated with spontaneous abortion (P < 0.001), thrombocytopenia (P < 0.01), livedo reticularis (P < 0.01) and a positive direct Coombs test (P < 0.05), but not with thrombosis or central nervous system diseases such as epilepsy and psychosis. IgM antibodies to cardiolipin were associated with a positive direct Coombs test (P < 0.01), but with no other symptom of antiphospholipid syndrome. The predictive values of anticardiolipin antibody determinations in unselected SLE patients were poor for all features of antiphospholipid syndrome because of high proportions of false-positive and false-negative results. As for other manifestations of SLE, positive correlations between raised antibodies to double-stranded DNA and the occurrence of anticardiolipin antibodies of the IgG isotype were observed, and anticardiolipin IgM was negatively associated with nephritis.