Central corneal thickness and intraocular pressure in a Mongolian population
Central corneal thickness and intraocular pressure in a Mongolian population
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DOI：
10.1016/s0161-6420(98)96021-3
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发表时间：
1998-06-01
期刊：
影响因子：
13.7
通讯作者：
Johnson, GJ
中科院分区：
文献类型：
--
作者：
Foster, PJ;Baasanhu, J;Johnson, GJ
目的：该研究的目的是量化东亚人群中央角膜厚度（CCT）的变化，并检查其与压平眼压计（IOP）估计值的关系。设计：该研究设计是一项横断面的、基于人群的调查。参与者：1242名居民的Hovsgol省，蒙古，10至87岁的volatile.Main结果measures：CCT测量使用光学厚度计在所有科目。在40岁及以上的受试者中使用Goldmann型压平眼压计测量IOP。结果：CCT随年龄的增加而显著降低：男性为5 μ m/10年，女性为6 μ m/10年（均P <0.0001）。IOP与CCT之间存在高度显著的正相关。线性回归分析表明，在40岁至80岁之间，CCT增加10 μ m与右眼IOP测量值增加0.18 mmHg（95%置信区间，0.12 - 0.25）和左眼IOP测量值增加0.24 mmHg（95%置信区间，0.17 - 0.31）相关。作者计算，CCT的个体间差异可能会产生2.3和3.1毫米汞柱之间的测量IOP的差异。结论：CCT的变化是个体之间的IOP测量的变化的一个重要来源。作者建议，在评估眼内压作为东亚人青光眼的危险因素时，应考虑测量角膜厚度。
Objective: The purpose of the study was to quantify the variation of central corneal thickness (CCT) in an east Asian population and to examine its relationship to estimates of intraocular pressure (IOP) made with an applanation tonometer.Design: The study design was a cross-sectional, population-based survey.Participants: One thousand two-hundred forty-two residents of Hovsgol Province, Mongolia, 10 to 87 years of age participated.Main Outcome Measures: The CCT was measured using an optical pachymeter in all subjects. The IOP was measured using a Goldmann-type applanation tonometer in subjects 40 years of age and older.Results: There was a highly significant decrease in CCT with age: 5 mu m/decade in men and 6 mu m/decade in women (both, P < 0.0001). A highly significant positive correlation was identified between IOP and CCT. Linear regression analysis suggests that between the ages of 40 and 80 years, an increase in CCT of 10 mu m is associated with an increase in IOP measurements of 0.18 mmHg in right eyes (95% confidence interval, 0.12-0.25) and 0.24 mmHg in left eyes (95% confidence interval, 0.17-0.31). The authors calculate that interindividual differences in CCT may produce a difference in measured IOP of between 2.3 and 3.1 mmHg.Conclusions: Variation in CCT is a significant source of variation in IOP measurements between individuals. The authors suggest that measurement of corneal thickness should be considered when assessing IOP as a risk factor for glaucoma in east Asians.