Ca2+ influx stimulated by vasopressin is mediated by phosphoinositide hydrolysis in rat smooth muscle cells.
Ca2+ influx stimulated by vasopressin is mediated by phosphoinositide hydrolysis in rat smooth muscle cells.
复制标题
加压素刺激的 Ca2+ 流入是由大鼠平滑肌细胞中磷酸肌醇水解介导的。
DOI：
10.1016/0006-291x(89)92652-1
复制
发表时间：
1989
影响因子：
3.1
通讯作者：
Y. Oiso
中科院分区：
文献类型：
--
作者：
K. Kondo;O. Kozawa;K. Takatsuki;Y. Oiso
The mechanism of Ca2+influx stimulated by arginine vasopressin (AVP) was studied in cultured rat smooth muscle cells. AVP stimulated45Ca2+influx even in the presence of nifedipine, a Ca2+antagonist that inhibits voltage-dependent Ca2+channel. NaF, a GTP-binding protein activator, minicked the AVP-stimulated45Ca2+influx. The45Ca2+influx stimulated by a combination of AVP and NaF was not additive. The affinity of AVP receptor was decreased by guanosine 5′-0-(3-thiotriphosphate). Pertussis toxin failed to affect the AVP-stimulated45Ca2+influx. AVP did not stimulated cAMP production, but increased inositol trisphosphate generation. Both AVP-stimulated45Ca2+influx and inositol trisphosphate generation were inhibited by neomycin, a phospholipase C inhibitor, in a dose-dependent manner, and the patterns of both inhibitions were similar. These results suggest that, in rat smooth muscle cells, AVP-stimulated Ca2+influx is mediated exclusively through phosphoinositide hydrolysis.
G蛋白直接调节哺乳动物心脏钙通道。
DOI：
10.1126/science.2446390
发表时间：
1987
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Yatani,A;Codina,J;Imoto,Y;Reeves,JP;Birnbaumer,L;Brown,AM
通讯作者：
Brown,AM