Association of Air Pollution Exposures With High-Density Lipoprotein Cholesterol and Particle Number: The Multi-Ethnic Study of Atherosclerosis.
Association of Air Pollution Exposures With High-Density Lipoprotein Cholesterol and Particle Number: The Multi-Ethnic Study of Atherosclerosis.
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DOI：
10.1161/atvbaha.116.308193
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发表时间：
2017-05
期刊：
影响因子：
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通讯作者：
Kaufman JD
中科院分区：
文献类型：
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作者：
Bell G;Mora S;Greenland P;Tsai M;Gill E;Kaufman JD
空气污染与心血管疾病之间的关系可以通过高密度脂蛋白(HDL)的变化来解释。在动脉粥样硬化空气污染多种族研究(MESA Air)中，我们研究了空气污染与高密度脂蛋白(HDLc)和高密度脂蛋白颗粒数(HDLp)之间的横截面关系。研究参与者是6654名白人、非裔美国人、西班牙裔和中国人，年龄在45岁到84岁之间。我们使用基于精细尺度似然的时空模型和特定队列监测来估计个人住宅环境中的细颗粒物污染暴露(PM2.5)和黑碳(BC)浓度。考试前的暴露时间平均为12个月、3个月和2周。2000年分别用胆固醇氧化酶法和核磁共振波谱测定了高密度脂蛋白胆固醇和高密度脂蛋白胆固醇。我们使用多元线性回归来检验空气污染暴露与高密度脂蛋白指标之间的关系。高密度脂蛋白胆固醇(−)为1.68 mg/dL(95%可信区间：−2.86，−0.50)，与高密度脂蛋白胆固醇(−)0.55 mg/dL(95%可信区间：−1.13，0.03)密切相关。在3个月的平均时间内，PM2.5值升高5μg/m~3与高密度脂蛋白胆固醇降低相关(−0.64μ/L(95%可信区间：−1.01，−0.26)，而与高密度脂蛋白胆固醇(−)0.05 mg/dL(95%可信区间：−0.82，0.71)无关)。这些数据与空气污染暴露与高密度脂蛋白指标呈负相关的假设是一致的。
The relationship between air pollution and cardiovascular disease may be explained by changes in high-density lipoprotein (HDL). We examined the cross-sectional relationship between air pollution and both HDL cholesterol (HDL-C) and HDL particle number (HDL-P) in the Multi-Ethnic Study of Atherosclerosis Air Pollution study (MESA Air). Study participants were 6,654 white, African-American, Hispanic, and Chinese men and women, 45–84 years of age. We estimated individual residential ambient fine particulate pollution exposure (PM2.5) and black carbon (BC) concentrations using a fine-scale likelihood-based spatiotemporal model and cohort-specific monitoring. Exposure periods were averaged to 12 months, 3 months, and two weeks prior to exam. HDL-C and HDL-P were measured in the year 2000 using the cholesterol oxidase method and nuclear magnetic resonance spectroscopy, respectively. We used multivariable linear regression to examine the relationship between air pollution exposure and HDL measures. A 0.7 10−6m−1 higher exposure to black carbon (a marker of traffic-related pollution) averaged over a one year period was significantly associated with a lower HDL-C (−1.68 mg/dL (95% CI: −2.86, −0.50), and approached significance with HDL-P (−0.55 mg/dL (95% CI: −1.13, 0.03). In the three month averaging time period, a 5 μg/m3 higher PM2.5 was associated with lower HDL-P (−0.64 μmol/L (95% CI: −1.01, −0.26), but not HDL-C (−0.05 mg/dL (95% CI: −0.82, 0.71). These data are consistent with the hypothesis that exposure to air pollution is adversely associated with measures of HDL.