Phenotypic and Genotypic Characteristics of Small Colony Variants and Their Role in Chronic Infection.
Phenotypic and Genotypic Characteristics of Small Colony Variants and Their Role in Chronic Infection.
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DOI：
10.4137/mbi.s25800
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发表时间：
2015
影响因子：
--
通讯作者：
Maddocks SE
中科院分区：
文献类型：
--
作者：
Johns BE;Purdy KJ;Tucker NP;Maddocks SE
小菌落变异（SCV）细菌自发出现在明显同质的微生物种群中，主要是对环境压力的反应，如抗菌处理。它们表现出独特的表型特征，部分是由可遗传的遗传变化所赋予的。SCV的特征是生长缓慢，只占它们产生的种群的一小部分，但凭借其固有的弹性和宿主适应性而持续存在。因此，SCV在慢性感染中是有问题的，其中在感染的急性期期间施用抗微生物治疗但不能根除SCV，SCV留在宿主内引起复发或慢性感染。这篇综述讨论了一些表型和基因型的变化，使SCVs成功地在宿主环境中增殖的潜在病原体和策略，可以改善感染的分辨率SCVs存在。
Small colony variant (SCV) bacteria arise spontaneously within apparently homogeneous microbial populations, largely in response to environmental stresses, such as antimicrobial treatment. They display unique phenotypic characteristics conferred in part by heritable genetic changes. Characteristically slow growing, SCVs comprise a minor proportion of the population from which they arise but persist by virtue of their inherent resilience and host adaptability. Consequently, SCVs are problematic in chronic infection, where antimicrobial treatment is administered during the acute phase of infection but fails to eradicate SCVs, which remain within the host causing recurrent or chronic infection. This review discusses some of the phenotypic and genotypic changes that enable SCVs to successfully proliferate within the host environment as potential pathogens and strategies that could ameliorate the resolution of infection where SCVs are present.