Autophagic compound database: A resource connecting autophagy-modulating compounds, their potential targets and relevant diseases
Autophagic compound database: A resource connecting autophagy-modulating compounds, their potential targets and relevant diseases
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自噬化合物数据库：连接自噬调节化合物、其潜在靶标和相关疾病的资源
DOI：
10.1111/cpr.12403
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发表时间：
2018-06-01
影响因子：
8.5
通讯作者：
Liu, Bo
中科院分区：
文献类型：
--
作者：
Deng, Yiqi;Zhu, Lingjuan;Liu, Bo
目的自噬是真核细胞中一种高度保守的溶酶体降解过程，可通过囊泡运输途径消化长寿命蛋白质和受损细胞器。目前，自噬的机制已逐渐被阐明，因此，针对自噬的小分子药物的发现一直备受关注。到目前为止，一些与自噬相关的网络服务器已经在网上提供，以方便科学家方便地获得与自噬相关的信息，例如HADb，CTLPScanner，iLIR服务器和ncRDeathDB。然而，据我们所知，没有任何Web服务器提供的自噬调控化合物。方法根据已发表的文章，所有的化合物及其与自噬的关系进行了解剖。结果获得了大量自噬调控化合物的信息，包括化合物、作用靶点/通路和疾病等。ACDB是一个有价值的资源，用户可以访问300多个策划的小分子化合物与autophagy.ConclusionsAutophagic化合物数据库将有助于发现更多的新的治疗药物在不久的将来。
ObjectivesAutophagy, a highly conserved lysosomal degradation process in eukaryotic cells, can digest long-lived proteins and damaged organelles through vesicular trafficking pathways. Nowadays, mechanisms of autophagy have been gradually elucidated and thus the discovery of small-molecule drugs targeting autophagy has always been drawing much attention. So far, some autophagy-related web servers have been available online to facilitate scientists to obtain the information relevant to autophagy conveniently, such as HADb, CTLPScanner, iLIR server and ncRDeathDB. However, to the best of our knowledge, there is not any web server available about the autophagy-modulating compounds.MethodsAccording to published articles, all the compounds and their relations with autophagy were anatomized. Subsequently, an online Autophagic Compound Database (ACDB) () was constructed, which contained information of 357 compounds with 164 corresponding signalling pathways and potential targets in different diseases.ResultsWe achieved a great deal of information of autophagy-modulating compounds, including compounds, targets/pathways and diseases. ACDB is a valuable resource for users to access to more than 300 curated small-molecule compounds correlated with autophagy.ConclusionsAutophagic compound database will facilitate to the discovery of more novel therapeutic drugs in the near future.