Continuous cavitation designed for enhancing radiofrequency ablation via a special radiofrequency solidoid vaporization process
Continuous cavitation designed for enhancing radiofrequency ablation via a special radiofrequency solidoid vaporization process
复制标题
连续空化设计用于通过特殊的射频固体汽化工艺增强射频消融
DOI：
10.1021/acsnano.5b07486
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发表时间：
2016
期刊：
影响因子：
17.1
通讯作者：
Huixiong Xu
中科院分区：
文献类型：
--
作者：
Kung Zhang;Pei Li;Hangrong Chen;Xiaowan Bo;Xiaolong Li;Huixiong Xu
Lowering power output and radiation time during radiofrequency (RF) ablation is still a challenge. Although it is documented that metal-based magnetothermal conversion and microbubbles-based inertial cavitation have been tried to overcome above issues, disputed toxicity and poor magnetothermal conversion efficiency for metal-based nanoparticles and violent but transient cavitation for microbubbles are inappropriate for enhancing RF ablation. In this report, a strategy,i.e., continuous cavitation, has been proposed, and solid menthol-encapsulated poly lactide-glycolide acid (PLGA) nanocapsules have been constructed, as a proof of concept, to validate the role of such a continuous cavitation principle in continuously enhancing RF ablation. The synthesized PLGA-based nanocapsules can respond to RF to generate menthol bubblesviadistinctive radiofrequency solidoid vaporization (RSV) process, meanwhile significantly enhance ultrasound imaging for HeLa solid tumor, and further facilitate RF ablationviathe continuous cavitation, as systematically demonstrated bothin vitroandin vivo. Importantly, this RSV strategy can overcome drawbacks and limitations of acoustic droplet vaporization (ADV) and optical droplet vaporization (ODV), and will probably find broad applications in further cancer theranostics.
