Body mass index in male patients with COPD: correlation with low attenuation areas on CT
Body mass index in male patients with COPD: correlation with low attenuation areas on CT
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DOI：
10.1136/thx.2008.097543
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发表时间：
2009-01-01
期刊：
影响因子：
10
通讯作者：
Mishima, M.
中科院分区：
文献类型：
--
作者：
Ogawa, E.;Nakano, Y.;Mishima, M.
背景资料：慢性阻塞性肺疾病（COPD）的特征是存在由肺弹性丧失和/或气道狭窄引起的气流限制。肺弹性丧失的病理标志是肺气肿，气道壁重塑导致气道狭窄。使用CT，可以通过分别测量低衰减区域（LAA）和气道壁厚度/管腔面积来评估这些病变。如前所述，COPD可通过CT分为气道为主型、肺气肿为主型和混合型。在这项研究中，据推测，病人的体质可能与这些病变的相对贡献气流obstruction.Methods：CT被用来评估肺气肿和气道尺寸在201例COPD患者。肺气肿用左心耳体素百分比（LAA %）评估，气道病变用壁面积百分比（WA %）评估。结果：LAA %较高的表型（即肺气肿显性表型和混合表型）患者的体重指数（BMI）显著降低。BMI与LAA %相关（rho =-0.557，p
Background: Chronic obstructive pulmonary disease (COPD) is characterised by the presence of airflow limitation caused by loss of lung elasticity and/or airway narrowing. The pathological hallmark of loss of lung elasticity is emphysema, and airway wall remodelling contributes to the airway narrowing. Using CT, these lesions can be assessed by measuring low attenuation areas (LAA) and airway wall thickness/luminal area, respectively. As previously reported, COPD can be divided into airway dominant, emphysema dominant and mixed phenotypes using CT. In this study, it is postulated that a patient's physique may be associated with the relative contribution of these lesions to airflow obstruction.Methods: CT was used to evaluate emphysema and airway dimensions in 201 patients with COPD. Emphysema was evaluated using percentage of LAA voxels (LAA%) and airway lesion was estimated by percentage wall area (WA%). Patients were divided into four phenotypes using LAA% and WA%.Results: Body mass index (BMI) was significantly lower in the higher LAA% phenotype (ie, emphysema dominant and mixed phenotypes). BMI correlated with LAA% (rho = -0.557, p