Preparation of Liponanocapsules via Construction of Bio-Derived Capsule Wall on a Liposomal Template
Preparation of Liponanocapsules via Construction of Bio-Derived Capsule Wall on a Liposomal Template
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DOI：
10.1295/koron.2017-0023
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发表时间：
2017-01-01
影响因子：
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通讯作者：
Fukui, Yuuka
中科院分区：
文献类型：
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作者：
Fukui, Yuuka
基于聚电解质在脂质体模板上逐层组装的概念，我们制备了生物衍生的纳米胶囊，脂质体胶囊。这种方法允许多种聚合物的选择，从合成聚合物到生物衍生聚合物，如多肽、多糖和DNA。所得脂质胶囊表现出优异的性能，包括机械坚固性、物质释放控制和增强细胞膜渗透性。此外，我们提出了一种通过在脂质胶囊表面矿化磷酸钙来制备混合纳米胶囊的新策略。将获得的脂质胶囊通过干燥介导的纳米胶囊组装成独立的胶体膜。然后，它们通过磷酸钙矿化进一步交联，赋予它们功能特性，如机械坚固性和物质的持续释放。这种分层结构有利于其作为生物支架用于药物输送和组织再生。综上所述，脂质胶囊是一种可设计的材料，在各种领域，特别是化妆品和制药领域具有很大的应用潜力。
We prepared bioderived nanocapsules, liponanocapsules, based on the concept of layer-by-layer assembly of polyelectrolytes over a liposomal template. This approach allowed diverse selection of polymers, ranging from synthetic polymers to bioderived polymers such as polypeptides, polysaccharides and DNA. The resultant liponanocapsules exhibited excellent properties including mechanical robustness, controlled release of substances and enhanced cell membrane permeability. Furthermore, we presented a novel strategy for generating hybrid nanocapsules via mineralization of calcium phosphate on the surface of liponanocapsules. The obtained liponanocapsules were assembled into a freestanding colloidal membrane via drying-mediated assembly of nanocapsules. Then, they were further crosslinked by mineralization of calcium phosphate to impart them functional properties such as mechanical robustness and sustained release of substances. Such a hierarchical structure is advantageous in its use as a bioscaffold for drug delivery and tissue regeneration. In summary, the liponanocapsule is a designable material and holds great potential in its use in a variety of fields, especially cosmetics and pharmaceutics.